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508510 ZD 7288 - CAS 133059-99-1 - Calbiochem

A potent blocker of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) in heart and brain.

ZD 7288 - CAS 133059-99-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Zeneca, HCN Channel Blocker, ZD 7288, ZD-7288, ZD7288

Primary Target: HCN channel
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
133059-99-1C₁₅H₂₁ClN₄

Products

Catalogue NumberPackaging Qty/Pack
5085100001 Glass bottle 10 mg
Description
OverviewA potent blocker of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) in heart and brain tissue. Recently shown to also block Na(+) currents in DRG neurons and in HEK293 cells transfected with Na(v)1.4 plasmids. In voltage clamp experiments, it is shown to reduce Ih in a time- and concentration-dependent manner (IC50 = 2 mM). Suggested to behave as a lipophilic quaternary cation that can pass into the cell interior to block Ih channels in their closed state.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number508510
Brand Family Calbiochem®
SynonymsZeneca, HCN Channel Blocker, ZD 7288, ZD-7288, ZD7288
References
ReferencesWu, X., et al. 2012. Channels (Austin). 6, 438.
Harris, N.C., and Constanti, A. 1995. J. Neurophysiol. 74, 2366.
Product Information
CAS number133059-99-1
FormWhite solid
Hill FormulaC₁₅H₂₁ClN₄
Chemical formulaC₁₅H₂₁ClN₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHCN channel
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5085100001 04055977262032

Documentation

ZD 7288 - CAS 133059-99-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Wu, X., et al. 2012. Channels (Austin). 6, 438.
Harris, N.C., and Constanti, A. 1995. J. Neurophysiol. 74, 2366.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-January-2014 JSW
SynonymsZeneca, HCN Channel Blocker, ZD 7288, ZD-7288, ZD7288
DescriptionA potent blocker of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) in heart and brain tissue. Recently shown to also block Na(+) currents in DRG neurons and in HEK293 cells transfected with Na(v)1.4 plasmids. In voltage clamp experiments, it is shown to reduce Ih in a time- and concentration-dependent manner (IC50 = 2 mM). Suggested to behave as a lipophilic quaternary cation that can pass into the cell interior to block Ih channels in their closed state.
FormWhite solid
CAS number133059-99-1
Chemical formulaC₁₅H₂₁ClN₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWu, X., et al. 2012. Channels (Austin). 6, 438.
Harris, N.C., and Constanti, A. 1995. J. Neurophysiol. 74, 2366.