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648469 Troglitazone - CAS 97322-87-7 - Calbiochem

A α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ).

Troglitazone - CAS 97322-87-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Peroxisome proliferator-activated receptors γ (PPARγ)
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Overview

Key Spec Table

CAS #Empirical Formula
97322-87-7C₂₄H₂₇NO₅S

Products

Catalogue NumberPackaging Qty/Pack
648469-5MG Plastic ampoule 5 mg
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Description
OverviewA α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ). Also exhibits anti-proliferative and anti-inflammatory properties. Shown to induce cell cycle arrest and apoptosis in human hepatoma cells. Inhibits vascular smooth muscle cell (VSMC) migration by rapidly activating MEK/ERK pathway leading to the induction of c-fos and Ets-1 expression. Blocks PDGF-induced cell proliferation of pancreatic stellate and accelerates p21Cip1 turnover by inhibiting PKCδ signaling in VSMCs. Exerts positive inotropic effect via Ca2+ sensitization in the sarcoplasmic reticulum and inhibits Na+/H+ exchange activity and proliferation of macrovascular endothelial cells.
Catalogue Number648469
Brand Family Calbiochem®
References
ReferencesMasamune, A., et al. 2002. J. Biol. Chem. 277, 141.
Boyault, S., et al. 2001. FEBS Lett. 501, 24.
de Dios, S.T., et al. 2001. J. Diabetes Complications 15, 120.
Furuse, Y., et al. 2001. Br. J. Pharmacol. 133, 1307.
Ghanim, H., et al. 2001. J. Clin. Endocrinol. Metab. 86, 1306.
Goetze, S., et al. 2001. J. Cardiovasc. Pharmacol. 38, 909.
Koga, H., et al. 2001. Hepatology 33, 1087.
Rosen, E.D. and Spiegelman, B.M., 2001. J. Biol. Chem. 276, 37731.
Subbaramaiah, K., et al. 2001. J. Biol. Chem. 276, 12440.
Takashima, T., et al. 2001. Int. J. Oncol. 19, 465.
Takeda, K., et al. 2001. J. Biol. Chem. 276, 48950.
Tanaka, T., et al. 2001. Cancer Res. 61, 2424.
Wakino, S., et al. 2001. J. Biol. Chem. 276, 47650.
Product Information
CAS number97322-87-7
ATP CompetitiveN
FormWhite to yellow solid
Hill FormulaC₂₄H₂₇NO₅S
Chemical formulaC₂₄H₂₇NO₅S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetPeroxisome proliferator-activated receptors γ (PPARγ)
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Safety Information according to GHS
RTECSXJ5813130
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
648469-5MG 04055977262469