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613551 TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
552309-42-9C₁₉H₂₀N₄O₃S₂

Products

Catalogue NumberPackaging Qty/Pack
613551-5MG Glass bottle 5 mg
Description
OverviewAn aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). Fully blocks CaCC current in salivary gland cells at 10 µM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547) at 10 µM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels.
Catalogue Number613551
Brand Family Calbiochem®
SynonymsANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01
References
ReferencesDavis, A.J., et al. 2012 Br. J. Pharmacol.,/i> in press
Namkung, W., et al. 2011., J Biol Chem. in press.
Namkung, W., et al. 2011., FASEB J. in press.
Product Information
CAS number552309-42-9
FormOff-white powder
Hill FormulaC₁₉H₂₀N₄O₃S₂
Chemical formulaC₁₉H₂₀N₄O₃S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationTMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM).
Biological Information
Purity≥97% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
613551-5MG 04055977263824