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614310 TLR3/dsRNA Complex Inhibitor - Calbiochem

TLR3/dsRNA Complex Inhibitor acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki = 2.96 µM; Kd = 19 nM). Selectively antagonizes stimulated TLR3 signaling.

TLR3/dsRNA Complex Inhibitor - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor

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614310
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₈H₁₃ClFNO₃S

Products

Catalogue NumberPackaging Qty/Pack
614310-10MG Glass bottle 10 mg
Description
OverviewA thiophenecarboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki = 2.96 µM; Kd = 19 nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-α and IL-1β (IC90 = 27 µM) and NO production (IC50 = 3.44 µM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50 >> 100 µM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays).
Catalogue Number614310
Brand Family Calbiochem®
Synonyms(R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor
References
ReferencesCheng, K., et al. 2011. J. Am. Chem. Soc. 133, 3764.
Product Information
FormWhite solid
Hill FormulaC₁₈H₁₃ClFNO₃S
Chemical formulaC₁₈H₁₃ClFNO₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationTLR3/dsRNA Complex Inhibitor acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki = 2.96 µM; Kd = 19 nM). Selectively antagonizes stimulated TLR3 signaling.
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
614310-10MG 04055977186628

Documentation

TLR3/dsRNA Complex Inhibitor - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

TLR3/dsRNA Complex Inhibitor - Calbiochem Certificates of Analysis

TitleLot Number
614310

References

Reference overview
Cheng, K., et al. 2011. J. Am. Chem. Soc. 133, 3764.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-August-2012 JSW
Synonyms(R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor
DescriptionA thiophenecarboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki = 2.96 µM; Kd = 19 nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-α and IL-1β (IC90 = 27 µM) and NO production (IC50 = 3.44 µM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50 >> 100 µM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₈H₁₃ClFNO₃S
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesCheng, K., et al. 2011. J. Am. Chem. Soc. 133, 3764.