574102 Sigma-AldrichSulindac Sulfide - CAS 32004-67-4 - Calbiochem
A cell-permeable, active metabolite of Sulindac.
More>> A cell-permeable, active metabolite of Sulindac. Less<<Synonyms: (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid
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Overview
Key Spec Table
CAS # | Empirical Formula |
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32004-67-4 | C₂₀H₁₇FO₂S |
Products
Catalogue Number | Packaging | Qty/Pack | |
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574102-5MG | Plastic ampoule | 5 mg |
Description | |
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Overview | A cell-permeable, active metabolite of Sulindac (Cat. No. 574100). Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits growth and induces apoptosis in prostate cancer cell lines. Selectively inhibits COX-1 (ID50 = 500 nM) compared to prostaglandin H synthase-2 (PGHS-2; COX-2; ID50 = 14 µM). Preferentially inhibits the secretion of Aβ42 in CHO cells stably transfected with both APP75, and the PS1 mutant M146L. |
Catalogue Number | 574102 |
Brand Family | Calbiochem® |
Synonyms | (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid |
Product Information | |
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CAS number | 32004-67-4 |
ATP Competitive | N |
Form | Yellow-orange solid |
Hill Formula | C₂₀H₁₇FO₂S |
Chemical formula | C₂₀H₁₇FO₂S |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | COX-1 |
Primary Target IC<sub>50</sub> | ID50 = 500 nM against COX-1 |
Purity | ≥98% by TLC |
Physicochemical Information | |
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Cell permeable | Y |
Storage and Shipping Information | |
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Ship Code | Ambient Temperature Only |
Toxicity | Harmful & Carcinogenic / Teratogenic |
Storage | +15°C to +30°C |
Do not freeze | Ok to freeze |
Global Trade Item Number | |
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Catalogue Number | GTIN |
574102-5MG | 04055977189551 |