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574102 Sulindac Sulfide - CAS 32004-67-4 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
32004-67-4C₂₀H₁₇FO₂S

Products

Catalogue NumberPackaging Qty/Pack
574102-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable, active metabolite of Sulindac (Cat. No. 574100). Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits growth and induces apoptosis in prostate cancer cell lines. Selectively inhibits COX-1 (ID50 = 500 nM) compared to prostaglandin H synthase-2 (PGHS-2; COX-2; ID50 = 14 µM). Preferentially inhibits the secretion of Aβ42 in CHO cells stably transfected with both APP75, and the PS1 mutant M146L.
Catalogue Number574102
Brand Family Calbiochem®
Synonyms(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid
References
ReferencesWeggen, S., et al. 2001. Nature 414, 212.
Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097.
Herrmann, C., et al. 1998. Oncogene 17, 1769.
Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105.
Arber, N., et al. 1997. Gastroenterology 113, 1892.
Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610.
Product Information
CAS number32004-67-4
ATP CompetitiveN
FormYellow-orange solid
Hill FormulaC₂₀H₁₇FO₂S
Chemical formulaC₂₀H₁₇FO₂S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetCOX-1
Primary Target IC<sub>50</sub>ID50 = 500 nM against COX-1
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Safety Information
R PhraseR: 22-42/43-63

Harmful if swallowed.
May cause sensitization by inhalation and skin contact.
Possible risk of harm to the unborn child.
S PhraseS: 36

Wear suitable protective clothing.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +15°C to +30°C
Do not freeze Ok to freeze
Global Trade Item Number
Catalogue Number GTIN
574102-5MG 04055977189551