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573127 STAT3 Inhibitor XII, SPI - Calbiochem

The STAT3 Inhibitor XII, SPI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

STAT3 Inhibitor XII, SPI - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: H₂N-FISKERERAILSTKPPGTFLLRFSESSK-CO₂H

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573127
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₄₆H₂₃₈N₄₀O₄₂

Products

Catalogue NumberPackaging Qty/Pack
573127-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable STAT3 SH2 domain-derived (588-615) 28-mer peptide that competitively prevents STAT3 binding to cognate pTyr peptide motif, represses STAT3 dimerization, induces apoptosis and acts as a selective constitutive STAT3 activation inhibitor in several tumor cells at 50 µM. Shown to localize in nucleus, potently block STAT3 phosphorylation, DNA-binding and transcriptional activities with minimal effect on STAT1, STAT5 and MEK signaling.
Catalogue Number573127
Brand Family Calbiochem®
SynonymsH₂N-FISKERERAILSTKPPGTFLLRFSESSK-CO₂H
References
ReferencesZhao, W., et al. 2010. J. Biol. Chem. 285, 35855.
Product Information
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₄₆H₂₃₈N₄₀O₄₂
Chemical formulaC₁₄₆H₂₃₈N₄₀O₄₂
Hygroscopic Hygroscopic
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Peptide SequenceH-Phe-Ile-Ser-Lys-Glu-Arg-Glu-Arg-Ala-Ile-Leu-Ser-Tyr-Lys-Pro-Pro-Gly-Tyr-Phe-Leu-Leu-Arg-Phe-Ser-Glu-Ser-Ser-Lys-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
573127-5MG 04055977266085

Documentation

STAT3 Inhibitor XII, SPI - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

STAT3 Inhibitor XII, SPI - Calbiochem Certificates of Analysis

TitleLot Number
573127

References

Reference overview
Zhao, W., et al. 2010. J. Biol. Chem. 285, 35855.

Technical Info

Title
JAK/STAT Signaling Research Focus
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-November-2012 JSW
SynonymsH₂N-FISKERERAILSTKPPGTFLLRFSESSK-CO₂H
DescriptionA cell-permeable STAT3 SH2 domain-derived (588-615) 28-mer peptide that competitively prevents STAT3 binding to cognate pTyr peptide motif, represses STAT3 dimerization, induces apoptosis and acts as a selective constitutive STAT3 activation inhibitor in several tumor cells at 50 µM. Shown to localize in nucleus, potently block STAT3 phosphorylation, DNA-binding and transcriptional activities with minimal effect on STAT1, STAT5 and MEK signaling.
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₄₆H₂₃₈N₄₀O₄₂
Peptide SequenceH-Phe-Ile-Ser-Lys-Glu-Arg-Glu-Arg-Ala-Ile-Leu-Ser-Tyr-Lys-Pro-Pro-Gly-Tyr-Phe-Leu-Leu-Arg-Phe-Ser-Glu-Ser-Ser-Lys-OH
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml) for H₂O (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesZhao, W., et al. 2010. J. Biol. Chem. 285, 35855.