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559410 SB 290157 - CAS 1140525-25-2 - Calbiochem

SB 290157, CAS 1140525-25-2, is a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC50 = 200 nM). Does not antagonize C5aR or other chemotactic GPCRs.

SB 290157 - CAS 1140525-25-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N²-[(2,2-Diphenylethoxy)acetyl]-L-arginine, TFA

Primary Target: C3a receptor
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Overview

Key Spec Table

CAS #Empirical Formula
1140525-25-2C₂₂H₂₈N₄O₄ · CF₃CO₂H

Products

Catalogue NumberPackaging Qty/Pack
559410-10MG Plastic ampoule 10 mg
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Description
OverviewA non-peptide that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC50 = 200 nM). Does not antagonize C5aR or other chemotactic G-protein-coupled receptors. Blocks C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca2+ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR (IC50 = 7, 12.5, and 27.7 nM, respectively). Also blocks C3a-mediated ATP release from Guinea pig platelets (IC50 = 30 nM). Exhibits anti-inflammatory properties. Supplied as a trifluoroacetate salt.
Catalogue Number559410
Brand Family Calbiochem®
SynonymsN²-[(2,2-Diphenylethoxy)acetyl]-L-arginine, TFA
References
ReferencesAmes, R.S., et al. 2001. J. Immunol. 166, 6341.
Product Information
CAS number1140525-25-2
ATP CompetitiveN
FormLyophilized
Hill FormulaC₂₂H₂₈N₄O₄ · CF₃CO₂H
Chemical formulaC₂₂H₂₈N₄O₄ · CF₃CO₂H
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationSB 290157, CAS 1140525-25-2, is a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC50 = 200 nM). Does not antagonize C5aR or other chemotactic GPCRs.
Biological Information
Primary TargetC3a receptor
Primary Target IC<sub>50</sub>200 nM against the anaphylatoxin C3a receptor; 7, 12.5, and 27.7 nM, in blocking C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca2+ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Do not reuse solutions diluted in physiological buffers.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
559410-10MG 04055977268140