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559285 RSK Inhibitor, SL0101

RSK Inhibitor, SL0101, CAS 77307-50-7, is a cell-permeable, selective, reversible, ATP-competitive RSK inhibitor (IC50 = 89 nM with 10 µM ATP). Blocks the proliferation of MCF-7 cell line.

RSK Inhibitor, SL0101 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Kaempferol-3-O-(3ʹʹ,4ʹʹ-di-O-acetyl-α-L-rhamnopyranoside), p90 Ribosomal S6 Kinase Inhibitor, SL0101

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559285
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
77307-50-7C₂₅H₂₄O₁₂

Products

Catalogue NumberPackaging Qty/Pack
559285-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC50 = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (Ki = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM. Also available as a 10 mM solution in DMSO (Cat. No. 559292).
Catalogue Number559285
Brand Family Calbiochem®
SynonymsKaempferol-3-O-(3ʹʹ,4ʹʹ-di-O-acetyl-α-L-rhamnopyranoside), p90 Ribosomal S6 Kinase Inhibitor, SL0101
References
ReferencesSmith, J.A., et al. 2007. Bioorg. Med. Chem. 15, 5018.
Smith, J.A., et al. 2006. Bioorg. Med. Chem. 14, 6043.
Xu, Y.M., et al. 2006. Bioorg. Med. Chem. 14, 3974.
Maloney, D.J. and Hecht, S.M., 2005. Org. Lett. 7, 1097.
Smith, J.A., et al. 2005. Cancer Res. 65, 1027.
Product Information
CAS number77307-50-7
FormYellow solid
Hill FormulaC₂₅H₂₄O₁₂
Chemical formulaC₂₅H₂₄O₁₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationRSK Inhibitor, SL0101, CAS 77307-50-7, is a cell-permeable, selective, reversible, ATP-competitive RSK inhibitor (IC50 = 89 nM with 10 µM ATP). Blocks the proliferation of MCF-7 cell line.
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
559285-1MG 04055977192360

Documentation

RSK Inhibitor, SL0101 SDS

Title

Safety Data Sheet (SDS) 

RSK Inhibitor, SL0101 Certificates of Analysis

TitleLot Number
559285

References

Reference overview
Smith, J.A., et al. 2007. Bioorg. Med. Chem. 15, 5018.
Smith, J.A., et al. 2006. Bioorg. Med. Chem. 14, 6043.
Xu, Y.M., et al. 2006. Bioorg. Med. Chem. 14, 3974.
Maloney, D.J. and Hecht, S.M., 2005. Org. Lett. 7, 1097.
Smith, J.A., et al. 2005. Cancer Res. 65, 1027.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-October-2014 JSW
SynonymsKaempferol-3-O-(3ʹʹ,4ʹʹ-di-O-acetyl-α-L-rhamnopyranoside), p90 Ribosomal S6 Kinase Inhibitor, SL0101
DescriptionA cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC50 = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (Ki = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number77307-50-7
Chemical formulaC₂₅H₂₄O₁₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Regulatory Review
ReferencesSmith, J.A., et al. 2007. Bioorg. Med. Chem. 15, 5018.
Smith, J.A., et al. 2006. Bioorg. Med. Chem. 14, 6043.
Xu, Y.M., et al. 2006. Bioorg. Med. Chem. 14, 3974.
Maloney, D.J. and Hecht, S.M., 2005. Org. Lett. 7, 1097.
Smith, J.A., et al. 2005. Cancer Res. 65, 1027.