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530746 Peroxiredoxin Inhibitor, Conoidin A - CAS 18080-67-6 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
18080-67-6C₁₀H₈Br₂N₂O₂

Products

Catalogue NumberPackaging Qty/Pack
5307460001 Glass bottle 25 mg
Description
OverviewA cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II in Toxoplasma gondii (TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC50 = 23 µM). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in Ancylostoma ceylanicum and human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number530746
Brand Family Calbiochem®
Synonyms2,3-bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor
References
ReferencesNguyen, J.B., et al. 2013. Chem. Biol. 20, 991.
Haraldsen, J. D., et al. 2009. Org. Biomol. Chem. 7, 3040.
Carey, K.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7433.
Product Information
CAS number18080-67-6
FormYelllowish brown solid
Hill FormulaC₁₀H₈Br₂N₂O₂
Chemical formulaC₁₀H₈Br₂N₂O₂
ReversibleN
Quality LevelMQ100
Biological Information
Primary TargetPeroxiredoxin
Primary Target IC<sub>50</sub>23 µM for blocking TgPrxII hyperperoxidation activity
Purity≥95% by NMR
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
5307460001 04055977242942