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506046 PRMT Inhibitor VII, DB867 - CAS 619334-60-0 - Calbiochem

A cell-permeable, selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC₅₀ = 9.5 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-[5-(4-Carbamimidoyl-phenyl)-furan-2-yl]-pyridine-2-carboxamidine

Primary Target: PRMT1
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
619334-60-0C₁₇H₁₅NO₅

Products

Catalogue NumberPackaging Qty/Pack
5060460001 Glass bottle 10 mg
Description
OverviewA cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC50 = 110 µM) and PRMT6 (IC50 = 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number506046
Brand Family Calbiochem®
Synonyms5-[5-(4-Carbamimidoyl-phenyl)-furan-2-yl]-pyridine-2-carboxamidine
References
ReferencesXu, J., et al, 2013. Mol. Cell. 51, 1.
Product Information
CAS number619334-60-0
FormYellow solid
Hill FormulaC₁₇H₁₅NO₅
Chemical formulaC₁₇H₁₅NO₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPRMT1
Primary Target IC<sub>50</sub>9 µ
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5060460001 04055977262681

Documentation

PRMT Inhibitor VII, DB867 - CAS 619334-60-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Xu, J., et al, 2013. Mol. Cell. 51, 1.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-March-2014 JSW
Synonyms5-[5-(4-Carbamimidoyl-phenyl)-furan-2-yl]-pyridine-2-carboxamidine
DescriptionA cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC50 = 110 µM) and PRMT6 (IC50 = 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number619334-60-0
Chemical formulaC₁₇H₁₅NO₅
Structure formulaStructure formula
Purity≥98% by HPLC
Solubility10% Aqueous Acetic Acid (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesXu, J., et al, 2013. Mol. Cell. 51, 1.