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505981 PK11195 - CAS 85532-75-8 - Calbiochem

PK11195 - CAS 85532-75-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: TSPO Activator II, Mitochondrial Translocator Protein Activator II, PK 11195, PK-11195, PK11195

Primary Target: peripheral bezodiazepine receptor
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
85532-75-8C₂₁H₂₁ClN₂O

Products

Catalogue NumberPackaging Qty/Pack
5059810001 Glass bottle 10 mg
Description
OverviewAn isoquinoline carboxamide that acts as a potent ligand for peripheral bezodiazepine receptor (Kd = 20 nM). Exhibits anti-inflammatory properties. Binds to monocytes and following lesioning its binding up-regulated in brain macrophages and activated microglia. Shown to enhance the susceptibility of cells to apoptosis induction by DNA damaging agents and can reverse the suppression of apoptosis by Bcl-2. Serves as a ligand of the outer membrane translocator protein and reduces mitochondrial transmembrane potential within 30 minutes of exposure (˜100 µM).
Catalogue Number505981
Brand Family Calbiochem®
SynonymsTSPO Activator II, Mitochondrial Translocator Protein Activator II, PK 11195, PK-11195, PK11195
References
ReferencesNaoi, M., et al., 2013. J. Neural Transm. In press
Casellas, P., et al., 2002. Neurochem. Int. 40, 475.
Waterfield, J.D., et al., 1999. Rheumtology 38, 1068.
Product Information
CAS number85532-75-8
FormWhite solid
Hill FormulaC₂₁H₂₁ClN₂O
Chemical formulaC₂₁H₂₁ClN₂O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetperipheral bezodiazepine receptor
Primary Target K<sub>i</sub>20 nM
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5059810001 04055977262537

Documentation

PK11195 - CAS 85532-75-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Naoi, M., et al., 2013. J. Neural Transm. In press
Casellas, P., et al., 2002. Neurochem. Int. 40, 475.
Waterfield, J.D., et al., 1999. Rheumtology 38, 1068.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-September-2013 JSW
SynonymsTSPO Activator II, Mitochondrial Translocator Protein Activator II, PK 11195, PK-11195, PK11195
DescriptionAn isoquinoline carboxamide that acts as a potent ligand for peripheral bezodiazepine receptor (Kd = 20 nM). Exhibits anti-inflammatory properties. Binds to monocytes and following lesioning its binding up-regulated in brain macrophages and activated microglia. Shown to enhance the susceptibility of cells to apoptosis induction by DNA damaging agents and can reverse the suppression of apoptosis by Bcl-2. Serves as a ligand of the outer membrane translocator protein and reduces mitochondrial transmembrane potential within 30 minutes of exposure (˜100 µM).
FormWhite solid
CAS number85532-75-8
Chemical formulaC₂₁H₂₁ClN₂O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesNaoi, M., et al., 2013. J. Neural Transm. In press
Casellas, P., et al., 2002. Neurochem. Int. 40, 475.
Waterfield, J.D., et al., 1999. Rheumtology 38, 1068.