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521233 PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409

Primary Target: PDGFR Tyrosine Kinase
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
627518-40-5C₁₈H₁₆FN₃O₂

Products

Catalogue NumberPackaging Qty/Pack
521233-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC50 < 33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC50 = 4.2 nM and 45 nM for -β and -α, respectively) and c-Abl (IC50 = 22 nM). Exhibits less activity towards Lck, c-Src, and Fyn (IC50 = 100 nM, 185 nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk's-1,-2,-4 &-7, bFGFR-1 and EGFR (IC50 = 3.1 µM, > 10 µM, > 10 µM, 45.8 µM and > 100 µM, respectively).
Catalogue Number521233
Brand Family Calbiochem®
Synonyms3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409
References
ReferencesHo, C.Y., et al. 2005. J. Med. Chem. 48, 8163.
Product Information
CAS number627518-40-5
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₁₈H₁₆FN₃O₂
Chemical formulaC₁₈H₁₆FN₃O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPDGFR Tyrosine Kinase
Primary Target IC<sub>50</sub>4.2 nM and 45 nM for -β and -α form of PDGFR, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
521233-1MG 04055977271379

Documentation

PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem Certificates of Analysis

TitleLot Number
521233

References

Reference overview
Ho, C.Y., et al. 2005. J. Med. Chem. 48, 8163.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-August-2008 RFH
Synonyms3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409
DescriptionA cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC50 <33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC50 = 4.2 nM and 45 nM for -β and -α, respectively) and c-Abl (IC50 = 22 nM). Exhibits less activity towards Lck, c-Src, and Fyn (IC50 = 100 nM, 185 nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk's-1,-2,-4 &-7, bFGFR-1 and EGFR (IC50 = 3.1 µM, >10 µM, >10 µM, 45.8 µM and >100 µM, respectively).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number627518-40-5
Chemical formulaC₁₈H₁₆FN₃O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesHo, C.Y., et al. 2005. J. Med. Chem. 48, 8163.