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530647 Orai1/CRAC Blocker, Cpd5J-4 - CAS 827001-82-1 - Calbiochem

A non-toxic thiourea derivative that acts as a blocker of Orai1, the pore subunit of Ca2+-release-activated Ca2+ (CRAC) in T cells

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Orai1 Inhibitor, CRAC Inhibitor, Ca2+ release-activated Ca2+ (CRAC) channel blocker

Primary Target: Orail1
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Overview

Key Spec Table

CAS #Empirical Formula
827001-82-1C₁₆H₁₂N₂O₃S

Products

Catalogue NumberPackaging Qty/Pack
5306470001 Glass bottle 10 mg
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Description
OverviewA non-toxic thiourea derivative that acts as a blocker of Orai1, the pore subunit of Ca2+-release-activated Ca2+ (CRAC) in T cells. Exhibits a strong blocking effect on store-operated Ca2+ entry in HeLa-O+S cells and in Th17 cells. Preferentially reduces Th17 differentiation and ameliorates Th17-mediated autoimmune disease. Blocks the infiltration of T cells into the CNS and reduces the number of IL-17 producing cells. Also shown to reduce the expression of retinoic acid receptor-related orphan receptors a (RORa) and RORgt. Reduces the symptoms and delays the onset of experimental autoimmune encephalomyelitis (EAE) in myelin oligodendrocyte glycoproteins 35-55 (MOG35-55) immunized mice (2 mg/kg, i.p.).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number530647
Brand Family Calbiochem®
SynonymsOrai1 Inhibitor, CRAC Inhibitor, Ca2+ release-activated Ca2+ (CRAC) channel blocker
References
ReferencesKim, K., et al. 2014. J Immunol. 192, 110.
Product Information
CAS number827001-82-1
FormOff-white powder
Hill FormulaC₁₆H₁₂N₂O₃S
Chemical formulaC₁₆H₁₂N₂O₃S
Quality LevelMQ100
Biological Information
Primary TargetOrail1
Purity≥98% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
5306470001 04055977260991