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504817 Mitochondrial Pyruvate Carrier Inhibitor, UK5099 - CAS 56396-35-1 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023

Primary Target: mitochondria
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
56396-35-1C₁₈H₁₂N₂O₂

Products

Catalogue NumberPackaging Qty/Pack
5048170001 Glass bottle 5 mg
5048170002 Glass bottle 25 mg
Description
OverviewA cell-permeable α-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50 nM in rat heart mitochondria; Ki ≤ 1 µM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2 µM in human myocytes and skeletal muscle myotubes).
Catalogue Number504817
Brand Family Calbiochem®
Synonyms(E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023
References
ReferencesDivakaruni, A.S., et al. 2013. Proc. Natl. acad. Sci. USA 110, 5422.
Bricker, D.K., et al. 2012. Science 337, 96.
Herzig, S., et al. 2012. Science 337, 93.
Hinoi, E., et al. 2006. Mol. Pharmacol. 70, 925.
Hildyard, J.C.W., et al. 2005. Biochim. Biophys. Acta 1707, 221.
Halestrap, A.P. 1978. Biochem. J. 172, 377.
Halestrap, A.P. 1975. Biochem. J. 145, 85.
Product Information
CAS number56396-35-1
FormBright yellow solid
Hill FormulaC₁₈H₁₂N₂O₂
Chemical formulaC₁₈H₁₂N₂O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetmitochondria
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for up to 2 weeks at -20°C or for up to 6 weeks at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5048170001 04055977244199
5048170002 04055977244205

Documentation

Mitochondrial Pyruvate Carrier Inhibitor, UK5099 - CAS 56396-35-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Divakaruni, A.S., et al. 2013. Proc. Natl. acad. Sci. USA 110, 5422.
Bricker, D.K., et al. 2012. Science 337, 96.
Herzig, S., et al. 2012. Science 337, 93.
Hinoi, E., et al. 2006. Mol. Pharmacol. 70, 925.
Hildyard, J.C.W., et al. 2005. Biochim. Biophys. Acta 1707, 221.
Halestrap, A.P. 1978. Biochem. J. 172, 377.
Halestrap, A.P. 1975. Biochem. J. 145, 85.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-July-2013 JSW
Synonyms(E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023
DescriptionA cell-permeable α-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50 nM in rat heart mitochondria; Ki ≤ 1 µM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2 µM in human myocytes and skeletal muscle myotubes).
FormBright yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number56396-35-1
Chemical formulaC₁₈H₁₂N₂O₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mg/ml). Use only fresh DMSO for reconstitution.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for up to 2 weeks at -20°C or for up to 6 weeks at -70°C.
Toxicity Standard Handling
ReferencesDivakaruni, A.S., et al. 2013. Proc. Natl. acad. Sci. USA 110, 5422.
Bricker, D.K., et al. 2012. Science 337, 96.
Herzig, S., et al. 2012. Science 337, 93.
Hinoi, E., et al. 2006. Mol. Pharmacol. 70, 925.
Hildyard, J.C.W., et al. 2005. Biochim. Biophys. Acta 1707, 221.
Halestrap, A.P. 1978. Biochem. J. 172, 377.
Halestrap, A.P. 1975. Biochem. J. 145, 85.