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FCMAB390F Milli-Mark® Anti-pan Histone-FITC Antibody, clone H11-4

This Milli-Mark Anti-pan Histone-FITC Antibody, clone H11-4 is validated for use in FC for the detection of pan Histone.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Histones
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FCMAB390F
100 tests  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFCMFITCMonoclonal Antibody
Description
Catalogue NumberFCMAB390F
Trade Name
  • Milli-Mark
DescriptionMilli-Mark® Anti-pan Histone-FITC Antibody, clone H11-4
Background InformationThere are 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. The five major classes of histones are H1/H5, H2A, H2B, H3, and H4. Histones H2A, H2B, H3 and H4 are known as the core histones, while histones H1 and H5 are known as the linker histones. Histones feature a main globular domain and a long N terminal tail which are involved with the structure of the nucleosomes of the 'beads on a string' structure. They are the chief protein components of chromatin, acting as spools around which DNA winds, and play a role in gene regulation.
Product Information
FormatFITC
Control
  • HeLa cells
PresentationPurified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Quality LevelMQ100
Applications
ApplicationThis Milli-Mark Anti-pan Histone-FITC Antibody, clone H11-4 is validated for use in FC for the detection of pan Histone.
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenPurified nuclear fractions of HeLa cells
CloneH11-4
HostMouse
SpecificityThe antibody binds specifically to an antigen determinant, which is present on all five histone proteins. The antibody recognizes the histones H1, H2A, H2B, H3 and H4 with comparable sensitivity.
IsotypeIgG1
Species Reactivity
  • Human
Species Reactivity NoteDue to the highly conserved nature of histones, this antibody is predicted to have wide species reactivity.
Antibody TypeMonoclonal Antibody
Purification MethodProtein A Purfied
Molecular WeightAntibody recognizes histones H1, H2A, H2B, H3, and H4. Calculated molecular weight for these histones range from 14 to 21 kDa.
Product Usage Statements
Quality AssuranceEvaluated by flow cytometry using HeLa cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size100 tests
Global Trade Item Number
Catalogue Number GTIN
FCMAB390F 04053252420856