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FCMAB302F Milli-Mark™ Anti-Brachyury-FITC Antibody, clone 3E4.2

Milli-Mark Anti-Brachyury-FITC Antibody, clone 3E4.2 is an antibody against Brachyury for use in FC.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Stem Cell Research Research Sub-Category: Mesenchymal Stem Cells Gene Symbol: MGC104817, OTTHUMP00000017588, TF, TFT UniProt Number: O15178
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FCMAB302F
100 tests  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFCMFITCMonoclonal Antibody
Description
Catalogue NumberFCMAB302F
Trade Name
  • Milli-Mark
DescriptionMilli-Mark™ Anti-Brachyury-FITC Antibody, clone 3E4.2
Alternate Names
  • T brachyury (mouse) homolog
  • T brachyury-like
  • T protein
  • T, brachyury homolog (mouse)
  • transcription factor T
Background InformationThe Brachyury protein is a T-box transcription factor that is one of the earliest indicators of mesoderm formation during embryonic development. As the brachyury protein family is essential for the formation of the posterior body in all vertebrates, Brachyury has been shown to be expressed during gastrula and neurula stages, as well as in the developing notochord. Consequently, when mutations occur within the brachyury gene, severe vertebral malformations have been found to occur, as a direct result. In addition, current findings also indicate that the dysregulation of brachyury may also be linked to the formation of chordomas, which are malignant tumors that develop along the spine.
References
Product Information
FormatFITC
Control
  • mouse ES cells (CMTI-2)
PresentationPurified mouse monoclonal IgG1k conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Quality LevelMQ100
Applications
ApplicationMilli-Mark Anti-Brachyury-FITC Antibody, clone 3E4.2 is an antibody against Brachyury for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenSynthetic human brachyury peptide, a.a. 224-435.
Clone3E4.2
HostMouse
SpecificityAntibody recognizes Brachyury.
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells.
Gene Symbol
  • MGC104817
  • OTTHUMP00000017588
  • TF
  • TFT
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O15178 # Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.

SIZE: 435 amino acids; 47443 Da

SUBUNIT: Monomer (By similarity).

Nucleus.

DISEASE: SwissProt: O15178 # Genetic variations in T are associated with susceptibility to neural tube defects (NTD) [MIM:182940]. NTD are common congenital malformations. Spina bifida, which results from malformations in the caudal region of the neural tube, is compatible with life but associated with significant morbidity, including lower limb paralysis.

SIMILARITY: SwissProt: O15178 ## Contains 1 T-box DNA-binding domain. ...
Molecular Weight 47 kDa Calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by flow cytometry using mouse ES cells (CMTI-2)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.
Packaging Information
Material Size100 tests
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
FCMAB302F 04053252681363

Documentation

Milli-Mark™ Anti-Brachyury-FITC Antibody, clone 3E4.2 SDS

Title

Safety Data Sheet (SDS) 

Milli-Mark™ Anti-Brachyury-FITC Antibody, clone 3E4.2 Certificates of Analysis

TitleLot Number
Milli-Mark Anti-Brachyury-FITC, clone 3E4.2 - 1992659 1992659
Milli-Mark Anti-Brachyury-FITC, clone 3E4.2 - 2000054 2000054
Milli-Mark Anti-Brachyury-FITC, clone 3E4.2 - 2056711 2056711
Milli-Mark Anti-Brachyury-FITC, clone 3E4.2 - 2228136 2228136
Milli-Mark Anti-Brachyury-FITC, clone 3E4.2 - NG1922968 NG1922968
Milli-Mark Anti-Brachyury-FITC, clone 3E4.2 - NRG1824158 NRG1824158
Milli-Mark Anti-Brachyury-FITC, clone 3E4.2 Conjugate - 2196077 2196077
Milli-Mark™ Anti-Brachyury-FITC, -2782660 2782660
Milli-Mark™ Anti-Brachyury-FITC, clone 3E4.2 3072324
Milli-Mark™ Anti-Brachyury-FITC, clone 3E4.2 - 3035167 3035167
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Catalogue Number Description
04-135 Anti-Brachyury Antibody, clone 3E4.2

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Categories

Life Science Research > Antibodies and Assays > Primary Antibodies