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444289 Marimastat - CAS 154039-60-8 - Calbiochem

Marimastat, CAS 154039-60-8, is a broad-spectrum MMP inhibitor (IC50 = 5, 6, 200, 20, 2, 1.8 & 3.8 nM for MMP-1, -2, -3, -7, -8, -14 and TACE, respectively).

Marimastat - CAS 154039-60-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (2S,3R)-N⁴-((1S)-2,2-Dimethyl-1-((methylamino)carbonyl)propyl)-N¹,2-hydroxy-3-(2-methylpropyl)butanediamide, BB-2516

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
154039-60-8C₁₅H₂₉N₃O₅

Products

Catalogue NumberPackaging Qty/Pack
444289-5MG Plastic ampoule 5 mg
Description
OverviewAn orally active peptidyl hydroxamate-based broad-spectrum MMP inhibitor (IC50 in nM = 5, 6, 200, 20, 2, 1.8 and 3.8 for MMP-1, -2, -3, -7, -8, -14 and TACE, respectively) that targets both the substrate binding site and the active-site Zn2+. Marimastate is widely used in studying the involvement of MMPs in various cellular and pathological processes both in vitro and in vivo.
Catalogue Number444289
Brand Family Calbiochem®
Synonyms(2S,3R)-N⁴-((1S)-2,2-Dimethyl-1-((methylamino)carbonyl)propyl)-N¹,2-hydroxy-3-(2-methylpropyl)butanediamide, BB-2516
References
ReferencesHansen, H.P., et al. 2002. Int. J. Cancer 98, 210.
Tsuji, F., et al. 2002. Cytokine 17, 294.
Barlaam, B., et al. 1999. J. Med. Chem. 42, 4890.
Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
Rasmussen, H.S., and McCann, P.P. 1997. Pharmacol. Ther. 75, 69.
Product Information
CAS number154039-60-8
FormWhite solid
Hill FormulaC₁₅H₂₉N₃O₅
Chemical formulaC₁₅H₂₉N₃O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationMarimastat, CAS 154039-60-8, is a broad-spectrum MMP inhibitor (IC50 = 5, 6, 200, 20, 2, 1.8 & 3.8 nM for MMP-1, -2, -3, -7, -8, -14 and TACE, respectively).
Biological Information
Purity≥98% by NMR
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36/37/39

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
444289-5MG 04055977186062

Documentation

Marimastat - CAS 154039-60-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Marimastat - CAS 154039-60-8 - Calbiochem Certificates of Analysis

TitleLot Number
444289

References

Reference overview
Hansen, H.P., et al. 2002. Int. J. Cancer 98, 210.
Tsuji, F., et al. 2002. Cytokine 17, 294.
Barlaam, B., et al. 1999. J. Med. Chem. 42, 4890.
Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
Rasmussen, H.S., and McCann, P.P. 1997. Pharmacol. Ther. 75, 69.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-August-2009 RFH
Synonyms(2S,3R)-N⁴-((1S)-2,2-Dimethyl-1-((methylamino)carbonyl)propyl)-N¹,2-hydroxy-3-(2-methylpropyl)butanediamide, BB-2516
DescriptionAn orally active peptidyl hydroxamate-based broad-spectrum MMP inhibitor (IC50 in nM = 5, 6, 200, 20, 2, 1.8 and 3.8 for MMP-1, -2, -3, -7, -8, -14 and TACE, respectively) that targets both the substrate binding site and the active-site Zn2+. Marimastate is widely used in studying the involvement of MMPs in various cellular and pathological processes both in vitro and in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number154039-60-8
Chemical formulaC₁₅H₂₉N₃O₅
Structure formulaStructure formula
Purity≥98% by NMR
SolubilityDMSO (15 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesHansen, H.P., et al. 2002. Int. J. Cancer 98, 210.
Tsuji, F., et al. 2002. Cytokine 17, 294.
Barlaam, B., et al. 1999. J. Med. Chem. 42, 4890.
Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
Rasmussen, H.S., and McCann, P.P. 1997. Pharmacol. Ther. 75, 69.