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505987 Keap1-Nrf2 Interaction Probe, ML334 - CAS 1432500-66-7 - Calbiochem

A cell-permeable, direct, non-covalent inhibitor of Keap1 - Nrf2 protein - protein interaction (Kd = 1 µM) that causes the dissociation of Nrf2 from keap1 in the cytosol.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (1S,2R)-2-((S)-1-((1,3-dioxoisoindolin-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclohexanecarboxylic acid, (SRS)-LH601, Nrf Activator VI

Primary Target: Keap1–Nrf2
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1432500-66-7C₂₆H₂₆N₂O₅

Products

Catalogue NumberPackaging Qty/Pack
5059870001 Glass bottle 10 mg
Description
OverviewA cell-permeable tetrahydroisoquinoline derivative that acts as a direct, non-covalent inhibitor of Keap1 - Nrf2 (Kelch-like ECH-associated protein 1 - nuclear factor erythroid 2-related factor 2) protein - protein interaction (Kd = 1 µM) that causes the dissociation of Nrf2 from keap1 in the cytosol. Exhibits ARE-inducing activity (EC50 = 18 µM in U2OS Keap1-Nrf2 functional assay) and promotes Nrf2 translocation to the nucleus (EC50 = 12 µM). Has good solubility in aqueous buffers (>100 µM in phosphate buffered saline).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number505987
Brand Family Calbiochem®
Synonyms(1S,2R)-2-((S)-1-((1,3-dioxoisoindolin-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclohexanecarboxylic acid, (SRS)-LH601, Nrf Activator VI
References
ReferencesHu, L., et al, 2013, Bioorg. Med. Chem. Lett. 23, 3039.
Product Information
CAS number1432500-66-7
FormWhite to cream powder
Hill FormulaC₂₆H₂₆N₂O₅
Chemical formulaC₂₆H₂₆N₂O₅
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetKeap1–Nrf2
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5059870001 04055977262599

Documentation

Keap1-Nrf2 Interaction Probe, ML334 - CAS 1432500-66-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Hu, L., et al, 2013, Bioorg. Med. Chem. Lett. 23, 3039.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-October-2020 JSW
Synonyms(1S,2R)-2-((S)-1-((1,3-dioxoisoindolin-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclohexanecarboxylic acid, (SRS)-LH601, Nrf Activator VI
DescriptionA cell-permeable tetrahydroisoquinoline derivative that acts as a direct, non-covalent inhibitor of Keap1 - Nrf2 (Kelch-like ECH-associated protein 1 - nuclear factor erythroid 2-related factor 2) protein - protein interaction (Kd = 1 µM) that causes the dissociation of Nrf2 from keap1 in the cytosol. Exhibits ARE-inducing activity (EC50 = 18 µM in U2OS Keap1-Nrf2 functional assay) and promotes Nrf2 translocation to the nucleus (EC50 = 12 µM). Has good solubility in aqueous buffers (>100 µM in phosphate buffered saline).
FormWhite to cream powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1432500-66-7
Chemical formulaC₂₆H₂₆N₂O₅
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHu, L., et al, 2013, Bioorg. Med. Chem. Lett. 23, 3039.