422708 Sigma-AldrichKN-93 - CAS 139298-40-1 - Calbiochem
KN-93, CAS 139298-40-1, is a cell-permeable, reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM). Binds to the CaM binding site and prevents the association of CaM with CaMKII.
More>> KN-93, CAS 139298-40-1, is a cell-permeable, reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM). Binds to the CaM binding site and prevents the association of CaM with CaMKII. Less<<KN-93 - CAS 139298-40-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine)
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 139298-40-1 | C₂₆H₂₉CIN₂O₄S |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 422708-1MG | Plastic ampoule | 1 mg | |
| 422708-5MG | Plastic ampoule | 5 mg |
| Description | |
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| Overview | A cell-permeable, reversible and competitive inhibitor of rat brain CaM kinase II (Ki = 370 nM). Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effects on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH/3T3 cells. A 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422712) in DMSO is also available. |
| Catalogue Number | 422708 |
| Brand Family | Calbiochem® |
| Synonyms | 2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine) |
| Product Information | |
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| CAS number | 139298-40-1 |
| ATP Competitive | Y |
| Form | Off-white solid |
| Hill Formula | C₂₆H₂₉CIN₂O₄S |
| Chemical formula | C₂₆H₂₉CIN₂O₄S |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
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| Primary Target | cam kinase 2 |
| Primary Target K<sub>i</sub> | 370 nM against rat brain CaM kinase II |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 422708-1MG | 04055977187243 |
| 422708-5MG | 04055977187250 |
Documentation
KN-93 - CAS 139298-40-1 - Calbiochem SDS
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KN-93 - CAS 139298-40-1 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 422708 |
References
| Reference overview |
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| Fan, G.H., et al. 1999. Mol. Pharmacol. 56, 39. Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063. Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608. Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255. Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968. Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315. |
Brochure
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| Caspases and other Apoptosis Related Tools Brochure |