Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

579053 InSolution™ TAPI-1 - Calbiochem

InSolution™ TAPI-1, CAS 171235-71-5, is a 10 mM solution of TAPI-1 in DMSO. A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE.

InSolution™ TAPI-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: MMPs and TACE
View Products on Sigmaaldrich.com
579053
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₆H₃₇N₅O₅

Products

Catalogue NumberPackaging Qty/Pack
579053-500UG Plastic ampoule 500 μg
Description
Catalogue Number579053
Brand Family Calbiochem®
References
Product Information
ATP CompetitiveN
FormLiquid
FormulationA 10 mM (500 µg/100 µl) solution of TAPI-1 (Cat. No. 579051) in DMSO.
Hill FormulaC₂₆H₃₇N₅O₅
Chemical formulaC₂₆H₃₇N₅O₅
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationInSolution™ TAPI-1, CAS 171235-71-5, is a 10 mM solution of TAPI-1 in DMSO. A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE.
Biological Information
Primary TargetMMPs and TACE
Primary Target IC<sub>50</sub>8.09 µM, 3.61 µM in blocking constitutive and muscarinic receptor-stimulated sAAPα release in HEK 293 cells expressing M3 muscarinic receptors
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
579053-500UG 04055977265385

Documentation

InSolution™ TAPI-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ TAPI-1 - Calbiochem Certificates of Analysis

TitleLot Number
579053
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-September-2008 RFH
DescriptionA structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-α convertase; ADAM17). However, TAPI-1 is more stable in serum than TAPI-0. TAPI-1 Blocks the shedding of several cell surface proteins such as TNF-α, IL-6 receptor, and p60 and p80 TNF receptors. Inhibits constitutive (IC50 = 8.09 μM) and muscarinic receptor-stimulated (IC50 = 3.61 μM) sAPPa release in HEK-293 cells expressing muscarinic receptors. Also blocks the TACE-dependent constitutive release of co-transfected APP(695) (IC50 = 920 nM).
FormLiquid
FormulationA 10 mM (500 µg/100 µl) solution of TAPI-1 (Cat. No. 579051) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₆H₃₇N₅O₅
Structure formulaStructure formula
Purity≥97% by HPLC
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Irritant