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559397 InSolution™ SB 202190 - CAS 152121-30-7 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: InSolution™ p38 MAP Kinase Inhibitor II

Primary Target: P38β
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559397
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
152121-30-7C₂₀H₁₄FN₃O

Products

Catalogue NumberPackaging Qty/Pack
559397-1ML Glass bottle 1 ml
Description
Catalogue Number559397
Brand Family Calbiochem®
SynonymsInSolution™ p38 MAP Kinase Inhibitor II
References
ReferencesAjizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
Lee, L.C., et al. 1994. Nature 372, 739.
Product Information
CAS number152121-30-7
ATP CompetitiveY
FormLiquid
FormulationA 1 mg/ml solution of SB 202190 (Cat. No. 559388) in anhydrous DMSO.
Hill FormulaC₂₀H₁₄FN₃O
Chemical formulaC₂₀H₁₄FN₃O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetP38β
Primary Target IC<sub>50</sub>16 nM
Primary Target K<sub>i</sub>16 nM; 350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)
Purity≥98% by HPLC
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
559397-1ML 04055977192629

Documentation

InSolution™ SB 202190 - CAS 152121-30-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ SB 202190 - CAS 152121-30-7 - Calbiochem Certificates of Analysis

TitleLot Number
559397

References

Reference overview
Ajizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
Lee, L.C., et al. 1994. Nature 372, 739.

Citations

Title
  • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
  • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision07-April-2008 RFH
    SynonymsInSolution™ p38 MAP Kinase Inhibitor II
    DescriptionA potent and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (IC50 = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to block LDL expression in Hep52 cells.
    FormLiquid
    FormulationA 1 mg/ml solution of SB 202190 (Cat. No. 559388) in anhydrous DMSO.
    Intert gas (Yes/No) Packaged under inert gas
    Concentration Label Please refer to vial label for lot-specific concentration
    CAS number152121-30-7
    Chemical formulaC₂₀H₁₄FN₃O
    Structure formulaStructure formula
    Purity≥98% by HPLC
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
    Toxicity Irritant
    ReferencesAjizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
    Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
    Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
    Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
    Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
    Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
    Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
    Lee, L.C., et al. 1994. Nature 372, 739.
    Citation
  • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
  • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
    		•