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218705 InSolution™ Casein Kinase I Inhibitor, D4476 - Calbiochem

The InSolution™ Casein Kinase I Inhibitor, D4476 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: CK1, CK1d
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218705
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₃H₁₈N₄O₃

Products

Catalogue NumberPackaging Qty/Pack
218705-1MG Plastic ampoule 1 mg
Description
Catalogue Number218705
Brand Family Calbiochem®
References
ReferencesRena, G., et al. 2004. EMBO Reports 5, 60.
Product Information
ATP CompetitiveY
FormLiquid
FormulationA 10 mM (1 mg/251 µl) solution of Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) in DMSO
Hill FormulaC₂₃H₁₈N₄O₃
Chemical formulaC₂₃H₁₈N₄O₃
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCK1, CK1d
Primary Target IC<sub>50</sub>0.2 µM, 0.3 µM against CK1, CK1d, respectively
Purity≥95% by HPLC
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
218705-1MG 04055977202540

Documentation

InSolution™ Casein Kinase I Inhibitor, D4476 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ Casein Kinase I Inhibitor, D4476 - Calbiochem Certificates of Analysis

TitleLot Number
218705

References

Reference overview
Rena, G., et al. 2004. EMBO Reports 5, 60.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-August-2023 JSW
DescriptionA cell-permeable, potent, and relatively specific ATP-competitive inhibitor of CK1 (IC50 = 200 nM from S. pombe; 0.3 µM for CK1δ) and ALK5 (IC50 = 500 nM). A weak inhibitor of p38α MAP kinase (IC50 = 12 µM) and several other kinases tested, including PKB, SGK, and GSK-3β. Suppresses the site-specific phosphorylation (Ser322 and Ser325) and nuclear exclusion of FOXO1A in H4IIE hepatoma cells. Shown to be ~10-fold more potent than IC261 (Cat. No. 400090; IC50 = 2.5 µM for CK1).
FormLiquid
FormulationA 10 mM (1 mg/251 µl) solution of Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) in DMSO
Intert gas (Yes/No) Packaged under inert gas
Concentration Label Please refer to vial label for lot-specific concentration
Chemical formulaC₂₃H₁₈N₄O₃
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Toxicity Irritant
ReferencesRena, G., et al. 2004. EMBO Reports 5, 60.