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504744 InSolution™ Aphidicolin - CAS 38966-21-1 - Calbiochem

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
38966-21-1C₂₀H₃₄O₄

Products

Catalogue NumberPackaging Qty/Pack
5047440001 Glass bottle 1 mg
Description
Catalogue Number504744
Brand Family Calbiochem®
References
ReferencesBorner, M.M., et al. 1995. Cancer Res. 55, 2122.
Poluha, W., et al. 1995. Oncogene 10, 185.
Urbani, L., et al. 1995. Exp. Cell Res. 219, 159. Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311. Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909. Hubermann, J.A. 1981. Cell 23, 647.
Product Information
CAS number38966-21-1
FormLiquid
FormulationA 30 mM (1 mg/98 µL) sterile-filtered solution of Aphidicolin (Cat. No. 178273) in DMSO.
Hill FormulaC₂₀H₃₄O₄
Chemical formulaC₂₀H₃₄O₄
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetDNA polymerase α and δ
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 24/25

Avoid contact with skin and eyes.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5047440001 04055977244076

Documentation

InSolution™ Aphidicolin - CAS 38966-21-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Borner, M.M., et al. 1995. Cancer Res. 55, 2122.
Poluha, W., et al. 1995. Oncogene 10, 185.
Urbani, L., et al. 1995. Exp. Cell Res. 219, 159. Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311. Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909. Hubermann, J.A. 1981. Cell 23, 647.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-January-2014 JSW
DescriptionA cell-permeable tetracyclic diterpene antibiotic. Cell synchronization agent. Blocks the cell cycle at the early S-phase. Specific, non-competitive and reversible inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLaS3 cells, but inhibits vincristine (Cat. No. 677181)-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.
FormLiquid
FormulationA 30 mM (1 mg/98 µL) sterile-filtered solution of Aphidicolin (Cat. No. 178273) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number38966-21-1
Chemical formulaC₂₀H₃₄O₄
Structure formulaStructure formula
Purity≥98% by TLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions.
Toxicity Irritant
ReferencesBorner, M.M., et al. 1995. Cancer Res. 55, 2122.
Poluha, W., et al. 1995. Oncogene 10, 185.
Urbani, L., et al. 1995. Exp. Cell Res. 219, 159. Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311. Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909. Hubermann, J.A. 1981. Cell 23, 647.