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400087 HIF-2α Translation Inhibitor - CAS 882268-69-1 - Calbiochem

The HIF-2α Translation Inhibitor, also referenced under CAS 882268-69-1, controls the biological activity of HIF-2α. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Hypoxia-Inducible Factor-2α Translation Inhibitor, Methyl-3-(2-(cyano(methylsulfonyl)methylene)hydrazino)thiophene-2-carboxylate, HIF Inhibitor II

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400087
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
882268-69-1C₉H₉N₃O₄S₂

Products

Catalogue NumberPackaging Qty/Pack
400087-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable thienylhydrazone compound that suppresses the translation of cellular HIF-2α message by enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to the IRE (Iron-Responsive Element) region at the 5' UTR of the HIF-2α mRNA, exhibiting otherwise no effects toward the transcription of HIF-2α mRNA or the stability of HIF-2α mRNA and protein. Shown to reduce cellular protein levels of HIF-2α and HIF-2α target genes, including Glut-1, IGFBP3, and VEGF, in 786-O cells (5 to 10 µM final concentration) that express only the 2α isoform of hypoxia-inducible factor.
Catalogue Number400087
Brand Family Calbiochem®
SynonymsHypoxia-Inducible Factor-2α Translation Inhibitor, Methyl-3-(2-(cyano(methylsulfonyl)methylene)hydrazino)thiophene-2-carboxylate, HIF Inhibitor II
References
ReferencesZimmer, M., et al. 2008. Mol. Cell 32, 838.
Product Information
CAS number882268-69-1
FormAmber solid
Hill FormulaC₉H₉N₃O₄S₂
Chemical formulaC₉H₉N₃O₄S₂
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Purity≥95% (sum of two isomers)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
400087-10MG 04055977212341

Documentation

HIF-2α Translation Inhibitor - CAS 882268-69-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

HIF-2α Translation Inhibitor - CAS 882268-69-1 - Calbiochem Certificates of Analysis

TitleLot Number
400087

References

Reference overview
Zimmer, M., et al. 2008. Mol. Cell 32, 838.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsHypoxia-Inducible Factor-2α Translation Inhibitor, Methyl-3-(2-(cyano(methylsulfonyl)methylene)hydrazino)thiophene-2-carboxylate, HIF Inhibitor II
DescriptionA cell-permeable thienylhydrazone compound that suppresses the translation of cellular HIF-2α message by enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to the IRE (Iron-Responsive Element) region at the 5' UTR of the HIF-2α mRNA, exhibiting otherwise no effects toward the transcription of HIF-2α mRNA or the stability of HIF-2α mRNA and protein. Shown to reduce cellular protein levels of HIF-2α and HIF-2α target genes, including Glut-1, IGFBP3, and VEGF, in 786-O cells (5-10 µM final concentration) that express only the 2α isoform of hypoxia-inducible factor.
FormAmber solid
Intert gas (Yes/No) Packaged under inert gas
CAS number882268-69-1
Chemical formulaC₉H₉N₃O₄S₂
Structure formulaStructure formula
Purity≥95% (sum of two isomers)
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesZimmer, M., et al. 2008. Mol. Cell 32, 838.