371963 Sigma-AldrichH-89, Dihydrochloride - CAS 127243-85-0 - Calbiochem
H-89, Dihydrochloride, CAS 127243-85-0, is a cell-permeable, potent, selective, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 48 nM).
More>> H-89, Dihydrochloride, CAS 127243-85-0, is a cell-permeable, potent, selective, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 48 nM). Less<<Synonyms: N-[2-((p-Bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor III
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Overview
Key Spec Table
CAS # | Empirical Formula |
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127243-85-0 | C₂₀H₂₀BrN₃O₂S · 2HCl |
Products
Catalogue Number | Packaging | Qty/Pack | |
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371963-1MG | Plastic ampoule | 1 mg |
Description | |
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Overview | A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (Ki = 48 nM). Inhibits other kinases only at much higher concentrations: CaM kinase II (Ki = 29.7 µM), casein kinase I (Ki = 38.3 µM), myosin light chain kinase (Ki = 28.3 µM), protein kinase C (Ki = 31.7 µM), and ROCK-II (IC50 = 270 nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs) such as GEFI, GEFII, or Epac (exchange protein directly activated by cAMP). Enhances radiation-induced apoptosis in the human cell line BM 13674. A 10 mM (1 mg/193 µl) solution of H-89, 2HCl (Cat. No. 371962) in DMSO is also available. |
Catalogue Number | 371963 |
Brand Family | Calbiochem® |
Synonyms | N-[2-((p-Bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor III |
Product Information | |
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CAS number | 127243-85-0 |
ATP Competitive | Y |
Form | Clear to off-white crystalline film |
Hill Formula | C₂₀H₂₀BrN₃O₂S · 2HCl |
Chemical formula | C₂₀H₂₀BrN₃O₂S · 2HCl |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Applications | |
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Application | H-89, Dihydrochloride, CAS 127243-85-0, is a cell-permeable, potent, selective, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 48 nM). |
Biological Information | |
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Primary Target | PKA |
Primary Target K<sub>i</sub> | 48 nM for protein kinase A |
Purity | ≥99% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
371963-1MG | 04055977213522 |