344101 Sigma-AldrichFSB - CAS 891180-93-1 - Calbiochem
A fluorine analog of the amyloidophilic fluorescent probe BSB that crosses the blood-brain barrier and displays low toxicity.
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Synonyms: (E,E)-1-Fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 760988-03-2 | C₂₄H₁₇FO₆ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 344101-5MG | Plastic ampoule | 5 mg |
| Description | |
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| Overview | A fluorine analog of the amyloidophilic fluorescent probe BSB (Cat. No. 286895) that crosses the blood-brain barrier and displays low toxicity (LD50 > 80 mg/kg). Suitiable for non-invasive amyloid visualization in living transgenic Tg2576 mice by using 19F and 1H-MRI (Magnetic Resonance Imaging). Also useful for staining plaques and neurofibrillary tangles in brain tissue sections of Alzheimer's diseased patients with improved sensitivity, and reduced background. |
| Catalogue Number | 344101 |
| Brand Family | Calbiochem® |
| Synonyms | (E,E)-1-Fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene |
| References | |
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| References | Higuchi, M., et al. 2005. Nat. Neurosci. 8, 527. Sato, K., et al. 2004. Eur. J. Med. Chem. 39, 573. |
| Product Information | |
|---|---|
| CAS number | 760988-03-2 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₂₄H₁₇FO₆ |
| Chemical formula | C₂₄H₁₇FO₆ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Amyloidophilic fluorescent probe |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | N |
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| Toxicological Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 344101-5MG | 04055977215205 |
Documentation
FSB - CAS 891180-93-1 - Calbiochem SDS
| Title |
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FSB - CAS 891180-93-1 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 344101 |
References
| Reference overview |
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| Higuchi, M., et al. 2005. Nat. Neurosci. 8, 527. Sato, K., et al. 2004. Eur. J. Med. Chem. 39, 573. |