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215921 Chlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Chloro-10-[3ʹ-(dimethylamino)propyl]phenothiazine, HCl

Primary Target: Calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
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215921
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
69-09-0C₁₇H₁₉ClN₂S · HCl

Products

Catalogue NumberPackaging Qty/Pack
215921-500MG Alu drum 500 mg
Description
OverviewInhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 µM). Acts as a peripheral vasodilator. Acts as an inhibitor of lysosomal sphingomyelinase and of TNF-α production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC50 < 10 µM), and PLA2.
Catalogue Number215921
Brand Family Calbiochem®
Synonyms2-Chloro-10-[3ʹ-(dimethylamino)propyl]phenothiazine, HCl
References
ReferencesLee, M.S., et al. 2007. Cancer Res. 67, 11359.
Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
Vadas, P., et al. 1986. Agents Actions 19, 194.
Marshak, P.R., et al. 1985. Biochemistry 24, 144.
Product Information
CAS number69-09-0
ATP CompetitiveN
FormOff-white crystalline solid
Hill FormulaC₁₇H₁₉ClN₂S · HCl
Chemical formulaC₁₇H₁₉ClN₂S · HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCalmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
Primary Target IC<sub>50</sub>17 µM inhibiting calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
Purity≥99% by HPLC
Physicochemical Information
Cell permeableN
ContaminantsHeavy metals: ≤0.002%; iron: ≤0.001%; sulfate: ≤0.05%
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSSO1750000
Safety Information
R PhraseR: 25-26-36/37/38

Toxic if swallowed.
Very toxic by inhalation.
Irritating to eyes, respiratory system and skin.
S PhraseS: 22-26-36/37/39-45

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
215921-500MG 07790788048549

Documentation

Chlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Chlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem Certificates of Analysis

TitleLot Number
215921

References

Reference overview
Lee, M.S., et al. 2007. Cancer Res. 67, 11359.
Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
Vadas, P., et al. 1986. Agents Actions 19, 194.
Marshak, P.R., et al. 1985. Biochemistry 24, 144.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-April-2018 JSW
Synonyms2-Chloro-10-[3ʹ-(dimethylamino)propyl]phenothiazine, HCl
DescriptionInhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 µM). Acts as a peripheral vasodilator. An inhibitor of TNFα production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC50 < 10 µM), and PLA2.
FormOff-white crystalline solid
CAS number69-09-0
RTECSSO1750000
Chemical formulaC₁₇H₁₉ClN₂S · HCl
Structure formulaStructure formula
Purity≥99% by HPLC
ContaminantsHeavy metals: ≤0.002%; iron: ≤0.001%; sulfate: ≤0.05%
SolubilityH₂O (50 mg/ml) or Methanol (10 mg/ml)
Storage +15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.
Toxicity Toxic
Merck USA index14, 2185
ReferencesLee, M.S., et al. 2007. Cancer Res. 67, 11359.
Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
Vadas, P., et al. 1986. Agents Actions 19, 194.
Marshak, P.R., et al. 1985. Biochemistry 24, 144.

Related Products & Applications

Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Sphingomyelinase Kinase Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Nitric Oxide and Oxidative Stress > Nitric Oxide Synthase (NOS) Inhibitors