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218750 Caspase-3 Inhibitor III - CAS 285570-60-7 - Calbiochem

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
285570-60-7C₂₁H₃₁ClN₄O₁₁

Products

Catalogue NumberPackaging Qty/Pack
218750-1MG Plastic ampoule 1 mg
218750-5MG Plastic ampoule 5 mg
Description
OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10.
Catalogue Number218750
Brand Family Calbiochem®
SynonymsAc-DEVD-CMK
References
ReferencesMocanu, M.M., et al. 2000. Br. J. Pharmacol. 130, 197
Schrantz, N., et al. 1999. Cell Death Differ. 6, 445.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Product Information
CAS number285570-60-7
ATP CompetitiveN
FormWhite to off-white lyophilized solid or powder
Hill FormulaC₂₁H₃₁ClN₄O₁₁
Chemical formulaC₂₁H₃₁ClN₄O₁₁
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcaspase-3, caspase-6, caspase-7, caspase-8, caspase-10
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Asp-Glu-Val-Asp-CMK
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
218750-1MG 04055977219074
218750-5MG 04055977219081

Documentation

Caspase-3 Inhibitor III - CAS 285570-60-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase-3 Inhibitor III - CAS 285570-60-7 - Calbiochem Certificates of Analysis

TitleLot Number
218750

References

Reference overview
Mocanu, M.M., et al. 2000. Br. J. Pharmacol. 130, 197
Schrantz, N., et al. 1999. Cell Death Differ. 6, 445.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure

Citations

Title
  • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision09-April-2018 JSW
    SynonymsAc-DEVD-CMK
    DescriptionA potent cell-permeable and irreversible inhibitor of caspase-3, a member of the ICE-CED-3 family of cysteine proteases.
    FormWhite to off-white lyophilized solid or powder
    CAS number285570-60-7
    Chemical formulaC₂₁H₃₁ClN₄O₁₁
    Peptide SequenceAc-Asp-Glu-Val-Asp-CMK
    Structure formulaStructure formula
    Purity≥98% by HPLC
    Solubility20% Acetonitrile (in H₂O) (1 mg/ml)
    Storage Protect from moisture
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
    Toxicity Standard Handling
    ReferencesMocanu, M.M., et al. 2000. Br. J. Pharmacol. 130, 197
    Schrantz, N., et al. 1999. Cell Death Differ. 6, 445.
    Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
    Citation
  • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.