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03-34-0051 Calpeptin - CAS 117591-20-5 - Calbiochem

Calpeptin, CAS 117591-20-5, is a cell-permeable inhibitor of calpain 1 and 2 (ID50 = 52 nM for calpain-1; and 34 nM for calpain-2) and papain (ID50 = 138 nM)

Calpeptin - CAS 117591-20-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Benzyloxycarbonylleucyl-norleucinal

Primary Target: Calpain-1
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
117591-20-5C₂₀H₃₀N₂O₄

Products

Catalogue NumberPackaging Qty/Pack
03-34-0051-100MG Plastic ampoule 100 mg
03-34-0051-25MG Plastic ampoule 25 mg
03-34-0051-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable calpain inhibitor (ID50 = 52 nM for calpain-1; ID50 = 34 nM for calpain-2; ID50 = 138 nM for papain). Inhibits the Ca2+-stimulated cleavage of p35 to p25 by calpain. Modulates the processing of β-amyloid precursor protein to β-amyloid (Aβ). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore-induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
Catalogue Number03-34-0051
Brand Family Calbiochem®
SynonymsBenzyloxycarbonylleucyl-norleucinal
References
ReferencesLee, M.S., et al. 2000. Nature 405, 360.
Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
Shiba, E., et al. 1996. Anticancer Res. 16, 773.
Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
Product Information
CAS number117591-20-5
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₂₀H₃₀N₂O₄
Chemical formulaC₂₀H₃₀N₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCalpeptin, CAS 117591-20-5, is a cell-permeable inhibitor of calpain 1 and 2 (ID50 = 52 nM for calpain-1; and 34 nM for calpain-2) and papain (ID50 = 138 nM)
Biological Information
Primary TargetCalpain-1
Primary Target IC<sub>50</sub>ID50 = 52 nM for calpain-1; 34 nM for calpain-2; 138 nM for papain
Purity≥94% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Leu-Nle-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
03-34-0051-100MG 04055977206838
03-34-0051-25MG 04055977206845
03-34-0051-5MG 04055977206852

Documentation

Calpeptin - CAS 117591-20-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Calpeptin - CAS 117591-20-5 - Calbiochem Certificates of Analysis

TitleLot Number
03-34-0051

References

Reference overview
Lee, M.S., et al. 2000. Nature 405, 360.
Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
Shiba, E., et al. 1996. Anticancer Res. 16, 773.
Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.

Citations

Title
  • Rosenberger, G., et al. 2005. Journal of Biological Chemistry 280, 6879.
  • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision08-October-2007 JSW
    SynonymsBenzyloxycarbonylleucyl-norleucinal
    DescriptionA cell-permeable calpain inhibitor. Inactivates calpain I (ID50 = 52 nM), calpain II (ID50 = 34 nM), and papain (ID50 = 138 nM). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
    FormWhite to off-white solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number117591-20-5
    Chemical formulaC₂₀H₃₀N₂O₄
    Peptide SequenceZ-Leu-Nle-CHO
    Structure formulaStructure formula
    Purity≥94% by HPLC
    SolubilityDMF (5 mg/ml) or DMSO (5 mg/ml). Dissolve in a minimal amount of DMF or DMSO then add H₂O, buffer or medium just prior to use.
    Storage -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
    Toxicity Standard Handling
    ReferencesLee, M.S., et al. 2000. Nature 405, 360.
    Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
    Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
    Shiba, E., et al. 1996. Anticancer Res. 16, 773.
    Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
    Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
    Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
    Citation
  • Rosenberger, G., et al. 2005. Journal of Biological Chemistry 280, 6879.
  • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
    		•