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208724 Calpain Inhibitor IV - Calbiochem

Calpain Inhibitor IV, Z-LLY-FMK, CAS 133410-84-1, is a cell-permeable, potent, irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also blocks cathepsin L activity (k2 = 680,000 M-1s-1).

Calpain Inhibitor IV - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-LLY-FMK

Primary Target: calpain 2
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208724
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₀H₄₀FN₃O₆

Products

Catalogue NumberPackaging Qty/Pack
208724-1MG Plastic ampoule 1 mg
Description
OverviewA potent, cell-permeable, and irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also acts as an inhibitor of cathepsin L (k2 = 680,000 M-1s-1).
Catalogue Number208724
Brand Family Calbiochem®
SynonymsZ-LLY-FMK
References
ReferencesDutt, P., et al. 1998. FEBS Lett. 436, 367.
Angliker, H., et al. 1992. J. Med. Chem. 35, 216.
Product Information
ATP CompetitiveN
FormWhite to pale yellow solid
Hill FormulaC₃₀H₄₀FN₃O₆
Chemical formulaC₃₀H₄₀FN₃O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCalpain Inhibitor IV, Z-LLY-FMK, CAS 133410-84-1, is a cell-permeable, potent, irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also blocks cathepsin L activity (k2 = 680,000 M-1s-1).
Biological Information
Primary Targetcalpain 2
Primary Target IC<sub>50</sub>k₂ = 28,900 M⁻¹s⁻¹ in the inhibition of calpain II; k2 = 680,000 M⁻¹s⁻¹ in the inhibition of cathepsin L
Puritysingle spot by TLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Leu-Leu-Tyr-CH₂F
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
208724-1MG 04055977202694

Documentation

Calpain Inhibitor IV - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Calpain Inhibitor IV - Calbiochem Certificates of Analysis

TitleLot Number
208724

References

Reference overview
Dutt, P., et al. 1998. FEBS Lett. 436, 367.
Angliker, H., et al. 1992. J. Med. Chem. 35, 216.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure

Citations

Title
  • Georg Rosenberger, Andreas Gal and Kerstin Kutsche. (2005) αPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading. Journal of Biological Chemistry (280) 6879-6889.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision13-May-2013 JSW
    SynonymsZ-LLY-FMK
    DescriptionA potent, cell-permeable and irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also acts as an inhibitor of cathepsin L (k2 = 680,000 M-1s-1).
    FormWhite to pale yellow solid
    Chemical formulaC₃₀H₄₀FN₃O₆
    Peptide SequenceZ-Leu-Leu-Tyr-CH₂F
    Structure formulaStructure formula
    Puritysingle spot by TLC
    SolubilityDMSO (25 mg/ml)
    Storage Protect from moisture
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    Toxicity Standard Handling
    ReferencesDutt, P., et al. 1998. FEBS Lett. 436, 367.
    Angliker, H., et al. 1992. J. Med. Chem. 35, 216.
    Citation
  • Georg Rosenberger, Andreas Gal and Kerstin Kutsche. (2005) αPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading. Journal of Biological Chemistry (280) 6879-6889.
    		•