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SCT242 BioTracker CDg16 Activated Macrophage Probe

Small molecule green fluorescent probe specific for activated macrophages for imaging inflammation.

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SCT242
1 mg  
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Overview

Replacement Information
Description
Catalogue NumberSCT242
DescriptionBioTracker CDg16 Activated Macrophage Probe
OverviewThe BioTracker™ CDg16 Activated Macrophage Probe is a fluorescent probe used to detect M1 classically-activated macrophages that emits in the green spectrum for imaging and detection (Park, 2019).

Macrophages play a critical role in the innate immune response. Classically-activated or M1 macrophages are typically classified as proinflammatory. Identifying macrophages activated to induce inflammatory responses is therefore important when assessing inflammation during research into the progression and treatment of related diseases such as atherosclerosis, hepatitis, and cancer. Unlike many macrophage probes which cannot appropriately distinguish between M1 activated and non-activated cells.

Spectral Properties
Fluorescence images obtained by λex = 488 nm and emission at 520 nm.

Reference
Park, Sung-Jin, et al. "Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target." Nature communications 10.1 (2019): 1-7.
Alternate Names
  • Live Cell Imaging Probe
References
Product Information
Detection methodFluorescence
PresentationLyophilized. Yellow solid.
Quality LevelMQ100
Applications
ApplicationSmall molecule green fluorescent probe specific for activated macrophages for imaging inflammation.
Key Applications
  • Cell Based Assays
  • Flow Cytometry
  • Fluorescence
Application NotesLive cell fluorescent imaging
Biological Information
Molecular Weight597.54
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssurancePurity ≥ 98% confirmed by UPLC. Identification confirmed by H NMR, F NMR, LC-MS, and elemental analysis.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -20°C, dessicated and protected from light.
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
Packaging Information
Material Size1 mg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
SCT242 04065267532219