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MAB318-AF488 Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate is an antibody against Tyrosine Hydroxylase for use in Immunocytochemistry.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: TH, TYH UniProt Number: P07101
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MAB318-AF488
100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
Zebrafish, Ch, Fg, H, M, RICCMAlexaFluor®488Monoclonal Antibody
Description
Catalogue NumberMAB318-AF488
DescriptionAnti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate
Alternate Names
  • Tyrosine 3-monooxygenase
  • Tyrosine Hydroxylase
  • Tyrosine 3-hydroxylase
  • TH
Background InformationTyrosine 3-monooxygenase (EC 1.14.16.2; UniProt P07101; also known as Dystonia 14, TH, Tyrosine 3-hydroxylase) is encoded by the TH (also known as DYT14, DYT5b, TYH) gene (Gene ID 7054) in human. Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. TH enzymatic activity requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. Six isoforms of human TH exist as a result of alternative splicing (UniProt P07101-1 through P07101-6).
References
Product Information
FormatAlexaFluor®488
PresentationPurified mouse antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate is an antibody against Tyrosine Hydroxylase for use in Immunocytochemistry.
Key Applications
  • Immunocytochemistry
Application NotesThe unconjugated antibody (Cat. No. MAB318) is shown to be suitable also for Western blotting, immunohistochemistry, and immunoprecipitation applications.
Biological Information
ImmunogenTyrosine Hydroxylase purified from PC12 cells.
EpitopeOn the outside of the regulatory N-terminus of tyrosine hydroxylase.
CloneLNC1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityRecognizes an epitope on the outside of the regulatory N-terminus of tyrosine hydroxylase. Does not react with dopamine-beta-hydroxylase, phenylalanine hydroxylase, trytophan hydroxylase, dehydropteridine reductase, sepiapterin reductase, or phenethanolamine-N-methyl transferase (PNMT) by Western blotting using the unconjugated antibody (Cat. No. MAB318).
IsotypeIgG1κ
Species Reactivity
  • Zebrafish
  • Chicken
  • Frog
  • Human
  • Mouse
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • TH
  • TYH
Purification MethodProtein A Purfied
UniProt Number
Molecular Weight~59-63 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunocytochemistry in rat cortical neurons.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Tyrosine Hydroxylase in rat cortical neurons.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MAB318-AF488 04055977301168

Documentation

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate SDS

Title

Safety Data Sheet (SDS) 

Anti-Tyrosine Hydroxylase Antibody, clone LNC1, Alexa Fluor® 488 Conjugate Certificates of Analysis

TitleLot Number
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 3990647 3990647
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 3991543 3991543
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 4076671 4076671
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 4091251 4091251
Anti- Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 4124273 4124273
Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate -2888816 2888816
Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 3011479 3011479
Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 3185617 3185617
Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 3231935 3231935
Anti-Tyrosine Hydroxylase, clone LNC1, Alexa Fluor® 488 Conjugate - 3336234 3336234
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Brochure

Title
Neuroscience Solutions for productive research

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Categories

Life Science Research > Antibodies and Assays > Primary Antibodies