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MABT182 Anti-Rab5A Antibody, clone 7D8.1

This Anti-Rab5A Antibody, clone 7D8.1 is validated for use in Western Blotting and Immunohistochemistry for the detection of Rab5A.

Anti-Rab5A Antibody, clone 7D8.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: RAB5A, RAB5 UniProt Number: P20339
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MABT182
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABT182
DescriptionAnti-Rab5A Antibody, clone 7D8.1
Alternate Names
  • Ras-related protein Rab-5A
  • Rab5
Background InformationRab5A is a membrane associated Ras related GTPase that is required for endosome fusion with the plasma membrane. Rab5A also contributes to filopodia extension and other cellular cytoplasmic extensions. Rab5A plays important roles in cellular differentiation, neurogenesis, exocytosis and protein transport. Rab proteins are a large family of GTP-binding proteins that regulate cellular membrane traffic and organelle identity. When membrane bound, each Rab has a very specific cellular location and recognizes distinct subsets of intracellular membranes, which allows Rab proteins to act as as key cellular regulators, determining the recruitment of downstream effectors to the correct membrane at the correct time. Recent research indicates that the localization of Rab proteins happens by sensing the stored curvature elastic energy in the membrane and the specific RabGEFs (Rab-activating guanosine diphosphate/guanosine triphosphate exchange factors) that associate with a particular Rab. Rab5A associates with Rabex-5 and this association provides the determinants for Rab5A specific membrane targets.
References
Product Information
FormatPurified
HS Code3002 15 90
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ300
Applications
ApplicationThis Anti-Rab5A Antibody, clone 7D8.1 is validated for use in Western Blotting and Immunohistochemistry for the detection of Rab5A.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Rab5A in human testis tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human Rab5A.
Clone7D8.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • RAB5A
  • RAB5
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~24 kDa observed.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HEK-293 cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Rab5A in 10 µg of HEK-293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABT182 04053252983658