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AB4254 Anti-Proteinase-Activated Receptor 2 Antibody, NT, extracellular

This Anti-Proteinase-Activated Receptor 2 Antibody, N-terminal, extracellular is validated for use in IH(P) for the detection of Proteinase-Activated Receptor 2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Inflammation & Autoimmune Mechanisms Gene Symbol: F2RL1, PAR-2, PAR2, GPR11 UniProt Number: P55085
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AB4254
50 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HIH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB4254
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Proteinase-Activated Receptor 2 Antibody, NT, extracellular
Alternate Names
  • PAR-2
Background InformationThe Proteinase-activated receptor 2 (PAR2) is a member of the proteinase-activated receptor subfamily. It is activated through proteolytic exposure of an occult tethered ligand by trypsin and trypsin-like proteases. This is in contrast to other members of the subfamily which are activated by the protease thrombin. PAR2 has been implicated in acute inflammatory response, asthma, and pain transmission. PAR2 expression has been documented in the periphery. ESTs have been isolated from adrenal, brain, breast, heart/melanocyte/uterus, kidney, lung, and vessel libraries.
References
Product Information
FormatAffinity Purified
PresentationPeptide-affinity purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide
Quality LevelMQ100
Applications
ApplicationThis Anti-Proteinase-Activated Receptor 2 Antibody, N-terminal, extracellular is validated for use in IH(P) for the detection of Proteinase-Activated Receptor 2.
Key Applications
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenSynthetic peptide corresponding to a sequence within the N-terminal extracellular domain of human PAR2. The immunogen has 70% homology with mouse and 60% homology with rat.
EpitopeN-terminal, extracellular
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityRecognizes human PAR2. The specificity of this antibody has been confirmed by IHC staining of human pancreas.
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryCoagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.
Gene Symbol
  • F2RL1
  • PAR-2
  • PAR2
  • GPR11
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P55085 # Receptor for trypsin and trypsin-like enzymes coupled to G proteins that stimulate phosphoinositide hydrolysis. May have a role in the regulation of vascular tone.
SIZE: 397 amino acids; 44126 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle.
PTM: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
SIMILARITY: SwissProt: P55085 ## Belongs to the G-protein coupled receptor 1 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -70°C in undiluted aliquots for up to 12 months from date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size50 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB4254 04053252516115

Documentation

Anti-Proteinase-Activated Receptor 2 Antibody, NT, extracellular SDS

Title

Safety Data Sheet (SDS) 

Anti-Proteinase-Activated Receptor 2 Antibody, NT, extracellular Certificates of Analysis

TitleLot Number
RABBIT ANTI- PROTEINASE-ACTIVATED RECEPTOR 2 POLYCLONAL ANTIBODY - 2387491 2387491
RABBIT ANTI- PROTEINASE-ACTIVATED RECEPTOR 2 POLYCLONAL ANTIBODY 3079585
RABBIT ANTI- PROTEINASE-ACTIVATED RECEPTOR 2 POLYCLONAL ANTIBODY 2923372
RABBIT ANTI- PROTEINASE-ACTIVATED RECEPTOR 2 POLYCLONAL ANTIBODY 2906459
RABBIT ANTI- PROTEINASE-ACTIVATED RECEPTOR 2 POLYCLONAL ANTIBODY 2896177
RABBIT ANTI- PROTEINASE-ACTIVATED RECEPTOR 2 POLYCLONAL ANTIBODY - 2042698 2042698
RABBIT ANTI- PROTEINASE-ACTIVATED RECEPTOR 2 POLYCLONAL ANTIBODY - 2172679 2172679