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07-1223 Anti-Protein Phosphatase 2 C α/β Antibody

Detect Protein Phosphatase 2 C α/β using this Anti-Protein Phosphatase 2 C α/β Antibody validated for use in WB.

Anti-Protein Phosphatase 2 C α/β Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Kinases & Phosphatases Gene Symbol: PPM2C, PDPC, PDP1, FLJ32517, PDH, PDP, MGC119646, EC 3.1.3.43 UniProt Number: Q9P0J1
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07-1223
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
B, H, M, RWBRbPurifiedPolyclonal Antibody
Description
Catalogue Number07-1223
ReplacesAB4090
DescriptionAnti-Protein Phosphatase 2 C α/β Antibody
Alternate Names
  • Protein phosphatase 2C
  • Pyruvate dehydrogenase
  • Pyruvate dehydrogenase phosphatase, catalytic subunit 1
  • Lipoamide-phosphatase 1, mitochondrial precursor
  • Protein phosphatase 2C, magnesium-dependent, catalytic subunit
  • Pyruvate dehydrogenase (Lipoamide) phosphatase-phosphatase
  • Pyruvate dehydrogenase phosphatase
Background InformationPP-2 C α/β is heterodimer located in the mitochondrial matrix. Within the pyruvate dehydrogenase complex, PP-2 C α/β serves to catalyze the dephosphorylation and concomitant reactivation of the E1 component’s alpha subunit. Mutations occurring in the PDP1 gene are the cause of a disease known as pyruvate dehydrogenase deficiency (PDP deficiency), which leads to neurological dysfunction from lactic acidosis.
References
Product Information
FormatPurified
Control
  • L6 Cell Lysate
PresentationPurified immunoglobulin in phosphate buffered saline with 0.08% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect Protein Phosphatase 2 C α/β using this Anti-Protein Phosphatase 2 C α/β Antibody validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenPurified peptide conjugated to KLH.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityRecognizes the alpha/beta regulatory subunit isotype of protein phosphatase 2C (PP2C). PP 2C alpha/beta polyclonal antibody binds a 44-46 kDa protein.
Species Reactivity
  • Bovine
  • Human
  • Mouse
  • Rat
Species Reactivity NoteProven to react with human and rat. Expected to react with mouse based on sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • PPM2C
  • PDPC
  • PDP1
  • FLJ32517
  • PDH
  • PDP
  • MGC119646
  • EC 3.1.3.43
Purification MethodProtein Purified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q9P0J1 # Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity).
COFACTOR: Binds 2 magnesium ions per subunit (By similarity).
SIZE: 537 amino acids; 61054 Da
SUBUNIT: Heterodimer of a catalytic subunit and a FAD protein of unknown function (By similarity).
SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
DISEASE:SwissProt: Q9P0J1 # Defects in PDP1 are the cause of pyruvate dehydrogenase phosphatase deficiency (PDP deficiency) [MIM:608782]. PDP deficiency results in lactic acidosis leading to neurological dysfunction.
SIMILARITY: SwissProt: Q9P0J1 ## Belongs to the PP2C family.
Molecular WeightApprox. 46 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in L6 cell lysates.
Western Blot Analysis: 1:500 dilution of this lot detected PP-2 C ALPHA/BETA on 10 ug of L6 lysates.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
07-1223 04053252409974