Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

MABN238 Anti-Glucagon Antibody, clone 13D11.33

Detect Glucagon using this Anti-Glucagon Antibody, clone 13D11.33 validated for use in IHC(P), Immunofluorescence, ELISA, Multiplexing.

Anti-Glucagon Antibody, clone 13D11.33 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Sensory & PNS Gene Symbol: GCG UniProt Number: P01275
View Products on Sigmaaldrich.com
MABN238
100 µg  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RIH(P), IF, ELISA, MplexMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN238
DescriptionAnti-Glucagon Antibody, clone 13D11.33
Alternate Names
  • 4030-01F
  • 4031-01F
  • AB932
Background InformationGlucagon is a hormone that is proteolytically cleaved into at least eight different functional peptides. It is produced by pancreatic cells and it has binding sites in the brain, intestines, and liver, among other tissues. Glucagon is secreted in response to hypoglycemia. Through the combined activation of Gsα- and Gq-coupled transmembrane receptors and their downstream signaling pathways, glucagon stimulates the release of glucose from the liver into the bloodstream. One important mechanism underlying this process is the activation of protein kinase A (PKA). PKA signals result in increased transcription of phosphoenolpyruvate carboxykinase, which encodes the rate-limiting enzyme in the production of glucose from noncarbohydrate substrates. PKA signals may also increase the breakdown of glycogen, and suppress glycolysis. Glucagon may also engage in calcium-dependent signaling via PLC. The importance of glucagon in regulating glucose homeostasis, in conjunction with insulin, is underscored by findings that glucagon and glucagon receptor signaling are disrupted in type II diabetes.
References
Product Information
FormatPurified
Control
  • Normal rat pancreas tissue
PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect Glucagon using this Anti-Glucagon Antibody, clone 13D11.33 validated for use in IHC(P), Immunofluorescence, ELISA, Multiplexing.
Key Applications
  • Immunohistochemistry (Paraffin)
  • Immunofluorescence
  • ELISA
  • Multiplexing
Application NotesImmunohistochemistry Analysis: A 1:8,000 dilution from a representative lot detected Glucagon in normal rat pancreas tissue (For enhanced staining results, it is recommended to use a 10,000 dilution of this antibody.).

ELISA Analysis: A representative lot detected Glucagon in ELISA.

Luminex® Analysis: A representative lot detected Glucagon in Luminex Assay.
Biological Information
ImmunogenOvalbumin-conjugated linear peptide corresponding to human Glucagon.
Clone13D11.33
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
IsotypeIgG2bκ
Species Reactivity
  • Human
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • GCG
Purification MethodProtein G Purified
UniProt Number
Molecular Weight21 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunofluorescence in normal rat pancreas tissue.

Immunofluorescence Analysis: A 1:8,000 dilution of this antibody detected Glucagon in normal rat pancreas tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABN238 04053252691966

Documentation

Anti-Glucagon Antibody, clone 13D11.33 SDS

Title

Safety Data Sheet (SDS) 

Anti-Glucagon Antibody, clone 13D11.33 Certificates of Analysis

TitleLot Number
Anti-Glucagon, clone 13D11.33 - 2424845 2424845
Anti-Glucagon, clone 13D11.33 - 2427501 2427501
Anti-Glucagon, clone 13D11.33 - 2438690 2438690
Anti-Glucagon, clone 13D11.33 - 2208803 2208803
Anti-Glucagon, clone 13D11.33 - 2315723 2315723
Anti-Glucagon, clone 13D11.33 - 2341101 2341101
Anti-Glucagon, clone 13D11.33 - 3488907 3488907
Anti-Glucagon, clone 13D11.33 - 3817615 3817615
Anti-Glucagon, clone 13D11.33 - 4004380 4004380
Anti-Glucagon, clone 13D11.33 - 4005710 4005710
Show more