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ABC346 Anti-FAF1 Antibody

Anti-FAF1 Antibody is a highly specific rabbit polyclonal antibody, that targets Fas-associated protein 1 & has been tested in western blotting & IHC.

Anti-FAF1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: FAF1 UniProt Number: Q9UNN5
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ABC346
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC346
DescriptionAnti-FAF1 Antibody
Alternate Names
  • Fas-associated protein 1
  • hFAF1
  • UBX domain-containing protein 12
  • UBX domain-containing protein 3A
  • UBXD12
  • UBXN3A
  • CGI-03
Background InformationFas-associated protein 1 (FAF1) is a member of the TNF receptor superfamily that plays a critical role in apoptosis during development and immune function. FAF1 has two amino-terminal domains with structural homology to ubiquitin. FAF1 has been observed to be one of the components of the death-inducing signaling complex (DISC) during Fas-mediated apoptosis and can bind to caspase-8 and FADD. Additionally, FAF1 has been shown to suppress the activation of the NF-kappaB transcription factor. FAF1 is also known to interact with the inflammatory signaling PYRIN-containing Apaf-1-like proteins (PYPAFs, also called NALPs) such as PYPAF1, PYPAF2 (NALP2), and PYPAF7, suggesting FAF1 may also be involved in the inflammation pathway. FAF1 is widely expressed with highest expression observed in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon.
References
Product Information
FormatAffinity Purified
Control
  • Jurkat cell lysate
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-FAF1 Antibody is a highly specific rabbit polyclonal antibody, that targets Fas-associated protein 1 & has been tested in western blotting & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected FAF1 in rat spleen tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human FAF1.
EpitopeC-terminus
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes the C-terminus of FAF1.
Species Reactivity
  • Human
  • Rat
Antibody TypePolyclonal Antibody
Gene Symbol
  • FAF1
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~78 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 2 isoforms at ~57 kDa and ~74 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in Jurkat cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected FAF1 in 15 µg of Jurkat cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABC346 04053252905094