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ABC116 Anti-EPS8, Antibody

This EPS8 antibody is validated for use in WB for the detection of the EPS8 protein.

Anti-EPS8, Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: EPS8 UniProt Number: Q12929
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ABC116
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, R, HWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC116
DescriptionAnti-EPS8, Antibody
Alternate Names
  • Epidermal growth factor receptor kinase substrate 8
  • EPS8
Background InformationEPS8 (epidermal growth factor receptor kinase substrate 8), which was originally identified as a substrate for the kinase activity of EGFR, is a multifunctional protein that is known to play a role in spermatogenesis, the regulation of actin, and other cellular processes. EPS8 uses its SH3 domain to complex with Abi1 and SOS1, leading to Rac activation and subsequent actin cytoskeletal remodeling. In the same manner, it binds with RN-tre to inhibit the internalization of EGFR. EPS8 also works with Arp3 to modulate actin dynamics within the seminiferous epithelium at the apical ES and the BTB.
References
Product Information
FormatAffinity Purified
Control
  • NIH/3T3 cell lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis EPS8 antibody is validated for use in WB for the detection of the EPS8 protein.
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human EPS8.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Mouse
  • Rat
  • Human
Species Reactivity NoteDemonstrated to react with Mouse. Predicted to react with Rat based on 100% sequence homology. Predicted to react with Human based on immunogen design.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • EPS8
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~97 kDa observed. A second isoform is known to exist at ~68 kDa. Uncharacterized bands may be observed at ~50 kDa and ~37 kDa in some cell lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in NIH/3T3 cell lysate.

Western Blot Analysis: 0.2 µg/mL of this antibody detected EPS8 in 10 µg of NIH/3T3 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABC116 04053252830808