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MABE634 Anti-CDKN1B , clone 3D8 Antibody

Anti-CDKN1B Antibody, clone 3D8 is an antibody against CDKN1B for use in Western Blotting.

Anti-CDKN1B , clone 3D8 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: CDKN1B, KIP1 UniProt Number: P46527
MABE634
100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBMAscitesMonoclonal Antibody
Description
Catalogue NumberMABE634
Replaces04-240
DescriptionAnti-CDKN1B , clone 3D8 Antibody
Alternate Names
  • Cyclin-dependent kinase inhibitor 1B
  • Cyclin-dependent kinase inhibitor p27
  • p27Kip1
  • CDKN1B
Background InformationCyclin-dependent kinase inhibitor 1B (CDKN1B) is a cell cycle regulatory mitotic inhibitor of cdk activity. CDKN1B is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. CDKN1B is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
References
Product Information
FormatAscites
PresentationMouse monoclonal IgG2ascitic fluid containing 0.03% sodium azide.
Quality LevelMQ300
Applications
ApplicationAnti-CDKN1B Antibody, clone 3D8 is an antibody against CDKN1B for use in Western Blotting.
Key Applications
  • Western Blotting
Biological Information
ImmunogenPurified recombinant fragment of human CDKN1B expressed in E. Coli.
Clone3D8
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG2
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Gene Symbol
  • CDKN1B
  • KIP1
Purification MethodUnpurified
UniProt Number
Molecular Weight~55 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in hIgGFc transfected HEK293 cell lysate
.

Western Blotting Analysis (WB): A 1:500-2,000 dilution of this antibody detected CDKN1B  in hIgGFc transfected HEK293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABE634 04055977172300