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MABE897 Anti-ATRX Antibody, clone 23C

Anti-ATRX Antibody, clone 23C is an antibody against ATRX for use in Western Blotting and Immunocytochemistry.

Anti-ATRX Antibody, clone 23C MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: ATRX, RAD54L, XH2 UniProt Number: P46100
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MABE897
100 μg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, ICCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABE897
DescriptionAnti-ATRX Antibody, clone 23C
Alternate Names
  • ATRX
  • Transcriptional regulator ATRX
  • ATP-dependent helicase ATRX
  • X-linked helicase II
  • X-linked nuclear protein
  • XNP
  • Znf-HX
Background InformationTranscriptional regulator ATRX (EC 3.6.4.12; UniProt P46100; also known as Alpha thalassemia/mental retardation syndrome X-linked, ATP-dependent helicase ATRX, DNA dependent ATPase and helicase, Helicase 2 X-linked, X-linked helicase II, X-linked nuclear protein, XNP, Zinc finger helicase, Znf-HX) is encoded by the PRF1 (Also known as ATR2, JMS, MRXHF1, RAD54, RAD54L, SFM1, SHS, XH2, XNP, ZNF-HX) gene in human (Gene ID 546). Rad54 belongs to the SWI/SNF family of chromatin remodeling proteins. Rad54 undergoes cell cycle-dependent phosphorylation, nuclear matrix and chromatin association, and is implicatetd in playing a role in gene regulation during interphase and mitosis. ATRX mutations are associated with an X-linked mental retardation (XLMR) syndrome. most often accompanied by alpha-thalassemia syndrome, as a result of diverse changes in DNA methylation.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-ATRX Antibody, clone 23C is an antibody against ATRX for use in Western Blotting and Immunocytochemistry.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesWestern Blotting Analysis: A representative lot detected ATRX in nuclear extracts from EBV-transformed lymphocytes (McDowell, T.L., et al. (1999). PNAS. 96(24):13983-13988).
Immunocytochemistry Analysis: A representative lot detected nuclear localization of ATRX in HeLa and L929 cells (McDowell, T.L., et al. (1999). PNAS. 96(24):13983-13988).
Biological Information
ImmunogenRecombinant protein corresponding to the N-terminus of human ATRX.
EpitopeN-terminus
Clone23C
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • ATRX
  • RAD54L
  • XH2
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~283 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected ATRX in 10 µg of HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABE897 04055977169867