Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

MABN124 Anti-ATF-3 Antibody, clone 13A5.1

Anti-ATF-3 Antibody, clone 13A5.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: ATF3 UniProt Number: P18847
View Products on Sigmaaldrich.com
MABN124
100 µL  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWBHuman RecombinantPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN124
DescriptionAnti-ATF-3 Antibody, clone 13A5.1
Alternate Names
  • Cyclic AMP-dependent transcription factor ATF-3
  • Activating transcription factor 3
  • cAMP-dependent transcription factor ATF-3
Background InformationCyclic AMP-dependent transcription factor ATF-3 (UniProt P18847; also known as Activating transcription factor 3, cAMP-dependent transcription factor ATF-3) is encoded by the ATF3 gene (Gene ID 467) in human. ATF-3 belongs to the ATF/cAMP-responsive element-binding protein family of basic leucine zipper-type transcription factors. ATF-3 is markedly induced and functions as either a transcriptional activator or repressor in response to LPS, cytokines, hormones, DNA damage, and ER stress in various cell types. ATF3 plays key roles in atherosclerosis and hyperlipidemia, and is reported to negatively regulate the differentiation of adipocyte, chondrocyte, and osteoblast. ATF-3 dysfunction is closely related to various inflammatory diseases and cancer.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
Key Applications
  • Western Blotting
Application NotesWestern Blotting Analysis: A 1:1,000 dilution of this antibody detected ATF-3 in 10 µg of RAW264.7 cell lysate.
Biological Information
ImmunogenGST-tagged recombinant human ATF-3 fragment.
Clone13A5.1
ConcentrationPlease refer to lot specific datasheet.
HostHuman Recombinant
SpecificityExpected to react with spliced isoforms 1 and 5 (UniProt P18847-1 and P18847-5). Reactivity toward spliced isoforms 2, 3, and 4 (UniProt P18847-2 through P18847-4) of human ATF-3 has not been determined.
IsotypeIgG2bκ
Species Reactivity
  • Human
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • ATF3
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~19 kDa observed.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in THP-1 cell lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected ATF-3 in 10 µg of THP-1 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABN124 04055977311884