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164605 Aminopeptidase N (CD13), Human Serum

Aminopeptidase N (CD13), Human Serum MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: APN/CD13, Aminopeptidase N

164605
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
164605-10UG Plastic ampoule 10 μg
Description
OverviewNative aminopeptidase N purified from human serum. Aminopeptidase N is a single-chain, integral membrane protease with broad specificity that functions to remove N-terminal amino acids from peptides. It also acts as a receptor for coronavirus and is known to play a role in angiogenesis, HIV entry, and in degradation of extracellular matrix as a result of tumor invasion.
Catalogue Number164605
Brand Family Calbiochem®
SynonymsAPN/CD13, Aminopeptidase N
References
ReferencesBhagwat, S.V., et al. 2003. Blood 101, 1818.
Kawai, M., et al. 2001. Clin. Chem. 47, 223.
Watanabe, Y., et al. 1998. Mol. Genet. Metab. 63, 289.
Pulido-Cejudo, G., et al. 1997. Antiviral Res. 36, 167.
Hansen, A.S., et al. 1993. Eur. J. Immunol. 23, 2358.
Saiki, I., et al. 1993. Int. J. Cancer 54,137.
Shipp, M.A. and Look, A.T. 1993. Blood 82, 1052.
Yeager, C.L., et al. 1992. Nature 357, 420.
Product Information
Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol L-leucine-p-nitroanilide) per min at 37°C, pH 7.2.
EC number3.4.11.2
FormLiquid
FormulationIn 150 mM NaCl, 50 mM Tris-HCl, 1 mM CaCl₂, pH 8.0.
Quality LevelMQ100
Applications
Biological Information
Purity≥92% by SDS-PAGE
SourcePrepared from human serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity≥450 mU/mg protein
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
164605-10UG 04055977207606

Documentation

Aminopeptidase N (CD13), Human Serum SDS

Title

Safety Data Sheet (SDS) 

Aminopeptidase N (CD13), Human Serum Certificates of Analysis

TitleLot Number
164605

References

Reference overview
Bhagwat, S.V., et al. 2003. Blood 101, 1818.
Kawai, M., et al. 2001. Clin. Chem. 47, 223.
Watanabe, Y., et al. 1998. Mol. Genet. Metab. 63, 289.
Pulido-Cejudo, G., et al. 1997. Antiviral Res. 36, 167.
Hansen, A.S., et al. 1993. Eur. J. Immunol. 23, 2358.
Saiki, I., et al. 1993. Int. J. Cancer 54,137.
Shipp, M.A. and Look, A.T. 1993. Blood 82, 1052.
Yeager, C.L., et al. 1992. Nature 357, 420.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-September-2007 RFH
SynonymsAPN/CD13, Aminopeptidase N
DescriptionNative aminopeptidase N purified from human serum. Aminopeptidase N is a single-chain, integral membrane protease with broad specificity that functions to remove N-terminal amino acids from peptides. It also acts as a receptor for coronavirus and is known to play a role in angiogenesis, HIV entry, and in degradation of extracellular matrix as a result of tumor invasion. Activity is inhibited by amastatin, actinonin, and bestatin (Cat. No. 200484) (~150 µM).
FormLiquid
FormulationIn 150 mM NaCl, 50 mM Tris-HCl, 1 mM CaCl₂, pH 8.0.
SourcePrepared from human serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
EC number3.4.11.2
Purity≥92% by SDS-PAGE
Specific activity≥450 mU/mg protein
Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol L-leucine-p-nitroanilide) per min at 37°C, pH 7.2.
Storage Avoid freeze/thaw
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Standard Handling
ReferencesBhagwat, S.V., et al. 2003. Blood 101, 1818.
Kawai, M., et al. 2001. Clin. Chem. 47, 223.
Watanabe, Y., et al. 1998. Mol. Genet. Metab. 63, 289.
Pulido-Cejudo, G., et al. 1997. Antiviral Res. 36, 167.
Hansen, A.S., et al. 1993. Eur. J. Immunol. 23, 2358.
Saiki, I., et al. 1993. Int. J. Cancer 54,137.
Shipp, M.A. and Look, A.T. 1993. Blood 82, 1052.
Yeager, C.L., et al. 1992. Nature 357, 420.