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533756 Ac-CoA Synthase Inhibitor - CAS 508186-14-9 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(2,3-di(Thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea, N-(2,3-di-2-Thienyl-6-quinoxalinyl)-Nʹ-(2-methoxyethyl)urea, Acyl-CoA Synthetase 2 short-chain Inhibitor; short-chain Acetyl-CoA Synthetase 2 Inhibitor, ACSS2 Inhibitor

Primary Target: ACSS2
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
508186-14-9C₂₀H₁₈N₄O₂S₂

Products

Catalogue NumberPackaging Qty/Pack
5337560001 Glass bottle 25 mg
Description
OverviewA cell-permeable quinoxaline based compound that acts as a potent, reversible inhibitor of acetyl CoA synthetase (ACSS2; IC50 ~ 600 nM in a luciferase based assay). Exhibits selectivity over ACSF2 and ACSL5 acyl-CoA synthetases. Efficiently blocks the uptake of 14C tracer carbons from acetate into lipids (IC50 = 6.8 µM) and for histone acetylation (IC50 = 5.5 µM) in HepG2 cells.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number533756
Brand Family Calbiochem®
Synonyms1-(2,3-di(Thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea, N-(2,3-di-2-Thienyl-6-quinoxalinyl)-Nʹ-(2-methoxyethyl)urea, Acyl-CoA Synthetase 2 short-chain Inhibitor; short-chain Acetyl-CoA Synthetase 2 Inhibitor, ACSS2 Inhibitor
References
ReferencesComerford, S.A., et al. 2014. Cell. 159, 1591.
Product Information
CAS number508186-14-9
FormYellow solid
Hill FormulaC₂₀H₁₈N₄O₂S₂
Chemical formulaC₂₀H₁₈N₄O₂S₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetACSS2
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5337560001 04055977286687

Documentation

Ac-CoA Synthase Inhibitor - CAS 508186-14-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Comerford, S.A., et al. 2014. Cell. 159, 1591.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-July-2017 JSW
Synonyms1-(2,3-di(Thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea, N-(2,3-di-2-Thienyl-6-quinoxalinyl)-Nʹ-(2-methoxyethyl)urea, Acyl-CoA Synthetase 2 short-chain Inhibitor; short-chain Acetyl-CoA Synthetase 2 Inhibitor, ACSS2 Inhibitor
DescriptionA cell-permeable quinoxaline based compound that acts as a potent, reversible inhibitor of acetyl CoA synthetase (ACSS2; IC50 ~ 600 nM in a luciferase based assay). Exhibits selectivity over ACSF2 and ACSL5 acyl-CoA synthetases. Efficiently blocks the uptake of 14C tracer carbons from acetate into lipids (IC50 = 6.8 µM) and for histone acetylation (IC50 = 5.5 µM) in HepG2 cells.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number508186-14-9
Chemical formulaC₂₀H₁₈N₄O₂S₂
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesComerford, S.A., et al. 2014. Cell. 159, 1591.