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12-539 Abltide, biotin conjugate

Abltide, biotin conjugate primarily used in Kinase Assays.

Abltide, biotin conjugate MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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12-539
500 µg  
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Overview

Replacement Information
Description
Catalogue Number12-539
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAbltide, biotin conjugate
OverviewDescription: Synthetic peptide (EAIYAAPFAKKK), biotinylated at the C-terminus.
References
Product Information
PresentationLyophilized
Quality LevelMQ100
Applications
ApplicationAbltide, biotin conjugate primarily used in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Entrez Gene Number
Entrez Gene SummaryThe ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.
Gene Symbol
  • ABL1
  • JTK7
  • ABL
  • p150
  • v-abl
  • c-ABL
  • bcr/abl
Protein TargetAbl
Target Sub-FamilyTK
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P00519 # Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.
COFACTOR: Magnesium or manganese.
SIZE: 1130 amino acids; 122873 Da
SUBUNIT: Interacts with SORBS1 following insulin stimulation. Found in a trimolecular complex containing CDK5 and CABLES1. Interacts with CABLES1 and PSTPIP1. Interacts with ZDHHC16 (By similarity). Interacts with INPPL1/SHIP2.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The myristoylated c-ABL protein is reported to be nuclear.
TISSUE SPECIFICITY: Widely expressed.
PTM: Phosphorylated by PRKDC (By similarity). DNA damage-induced activation of c-Abl requires the function of ATM and Ser-446 phosphorylation. Isoform IB is myristoylated on Gly-2.
DISEASE: SwissProt: P00519 # A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia (CML) [MIM:608232]. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
SIMILARITY: SwissProt: P00519 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated as a substrate for Abl kinase.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsLyophilized: 2 years at 4°C. Rehydrated: 6 months at -20°C
Packaging Information
Material Size500 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
12-539 04053252277627

Documentation

Abltide, biotin conjugate SDS

Title

Safety Data Sheet (SDS) 

Abltide, biotin conjugate Certificates of Analysis

TitleLot Number
Abltide, biotin conjugate 3095006
Abltide, biotin conjugate 2821275
Abltide, biotin conjugate - 2462713 2462713
Abltide, biotin conjugate - 1977961 1977961
Abltide, biotin conjugate - 26894 26894
Abltide, biotin conjugate - 3211153 3211153
Abltide, biotin conjugate - 3386414 3386414
Abltide, biotin conjugate - 3951337 3951337
Abltide, biotin conjugate - DAM1484470 DAM1484470
Abltide, biotin conjugate - DAM1770339 DAM1770339
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Alternative Format

Catalogue Number Description
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Categories

Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Kinase & Phosphatase Substrates
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Kinase & Phosphatase Substrates