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504377 AMPK Signaling Activator XIII, ZLN005 - CAS 4529-96-8 - Calbiochem

Calbiochem AMPK Activator, CAS 4529-96-8, inhibits luciferase activity, and activates AMPK signaling.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(4-tert-Butylphenyl)-1H-benzo[d]imidazole, 2-(4-(2-Methyl-2-propanyl)phenyl)-1H-benzimidazole, Luciferase Inhibitor IV

Primary Target: increases cellular ADP/ATP ratio via mitochondria respiration uncoupling
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Overview

Key Spec Table

CAS #Empirical Formula
4529-96-8C₁₇H₁₈N₂

Products

Catalogue NumberPackaging Qty/Pack
5043770001 Glass bottle 25 mg
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Description
OverviewA cell-permeable benzimidazole that, in addition to its inhibitory potency against luciferase activity (IC50 <10 nM), also activates AMPK signaling by increasing cellular ADP/ATP ratio via mitochondria respiration upcoupling, effectively activating AMPK & PGC-1α in muscle, but not liver, cell types both in cultures (5-20 µM in rat L6 myotubes) in vitro and in db/db mice (15 mg/kg/day via p.o.) in vivo. Reported to improve glucose and insulin tolerance of db/db mice without any apparent effects on body weight or food intake.
Catalogue Number504377
Brand Family Calbiochem®
Synonyms2-(4-tert-Butylphenyl)-1H-benzo[d]imidazole, 2-(4-(2-Methyl-2-propanyl)phenyl)-1H-benzimidazole, Luciferase Inhibitor IV
References
ReferencesZhang, L.N., et al. 2013. Diabetes. 62, 1297.
Product Information
CAS number4529-96-8
FormPinkish-white powder
Hill FormulaC₁₇H₁₈N₂
Chemical formulaC₁₇H₁₈N₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCalbiochem AMPK Activator, CAS 4529-96-8, inhibits luciferase activity, and activates AMPK signaling.
Biological Information
Primary Targetincreases cellular ADP/ATP ratio via mitochondria respiration uncoupling
Secondary targetluciferase activity inhibitor
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
5043770001 04055977264043