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123850 AKR1C1 Inhibitor, 5-PBSA - CAS 4906-68-7 - Calbiochem

The AKR1C1 Inhibitor, 5-PBSA, also referenced under CAS 4906-68-7, controls the biological activity of AKR1C1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Aldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA

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123850
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
4906-68-7C₁₃H₉BrO₃

Products

Catalogue NumberPackaging Qty/Pack
123850-25MG Glass bottle 25 mg
Description
OverviewA cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki = 4 nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki = 0.087, 4.2 and 18.2 µM, respectively). Shown to inhibit the metabolism of progesterone by AKR1C1 (IC50 = 460 nM in AKR1C1 overexpressing BAECs).
Catalogue Number123850
Brand Family Calbiochem®
SynonymsAldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA
References
ReferencesEl-Kabbani, O., et al. 2011. J. Steroid Biochem. Mol. Biol. 125, 105.
El-Kabbani, O., et al. 2009. J. Med. Chem. 52, 3259.
Product Information
CAS number4906-68-7
FormWhite solid
Hill FormulaC₁₃H₉BrO₃
Chemical formulaC₁₃H₉BrO₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥94% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
123850-25MG 04055977206296

Documentation

AKR1C1 Inhibitor, 5-PBSA - CAS 4906-68-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AKR1C1 Inhibitor, 5-PBSA - CAS 4906-68-7 - Calbiochem Certificates of Analysis

TitleLot Number
123850

References

Reference overview
El-Kabbani, O., et al. 2011. J. Steroid Biochem. Mol. Biol. 125, 105.
El-Kabbani, O., et al. 2009. J. Med. Chem. 52, 3259.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-July2-2012 JSW
SynonymsAldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA
DescriptionA cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki = 4 nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki = 0.087, 4.2 and 18.2 µM, respectively). Shown to inhibit the metabolism of progesterone by AKR1C1 (IC50 = 460 nM in AKR1C1 overexpressing BAECs).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number4906-68-7
Chemical formulaC₁₃H₉BrO₃
Structure formulaStructure formula
Purity≥94% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesEl-Kabbani, O., et al. 2011. J. Steroid Biochem. Mol. Biol. 125, 105.
El-Kabbani, O., et al. 2009. J. Med. Chem. 52, 3259.