Libraries/Panels - Competitive Comparisons |
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Signaling Pathway Panel & Library Applications & Characteristics
| Products | EMD Signaling Pathway Panels | EMD Libraries | Supplier S Libraries | Supplier B Libraries |
|---|---|---|---|---|
| Product Characteristics | ||||
| Format | IndividualΔ Vials |
96- or 384-well | 96 well | 96 well |
| Inhibitors per plate or kit | 12-16 | 80 or > 160 | 80 | 80 |
| Volume | Lyophilized (100 µg-5 mg) |
50 or 25 µl/well | 25 µl/well | 100 or 500 µl/well |
| Concentration | User determined | 10 mM | 10 mM | 10 mM |
| Example of Suitable Applications | ||||
| Cost-effective pathway analysis | +++ | ++ | ++ | ++ |
| Cell-based assays | +++ | +++ | + | + |
| Method development & validation | ++ | +++ | +++ | ++ |
| Target identification in drug discovery | ++ | +++ | +++ | + |
| Screening for cell phenotype | ++ | +++ | + | + |
| Screening of new kinases | + | +++ | + | + |
| Inhibitor Characteristics | ||||
| Cell-permeable* | +++ | +++ | Data not provided | Data not provided |
| Potent and Selective* | +++ | +++ | Data not provided | Data not provided |
| ATP-competitive* | +++ | +++ | Data not provided | Data not provided |
| Reversible* | +++ | +++ | Data not provided | Data not provided |
| HPLC purity >95%* | +++ | +++ | +++ | Data not provided |
| Structurally diverse | ++ | +++ | ++ | + |
| Pharmacologically active | +++ | +++ | +++ | Data not provided |
| Stable in DMSO and supplied with lot-specific HPLC data | +++ | +++ | Data not provided | Data not provided |
| Kit Contents and Documentation | ||||
| Lot specific data | +++ | +++ | Data not provided | Data not provided |
| Published IC50/Ki values | +++ | +++ | + | + |
| Literature citations | +++ | +++ | +++ | + |
| Inhibitor description | +++ | +++ | + | + |
| Molecular weight | +++ | +++ | +++ | +++ |
| Molecular structure | +++ | +++ | +++ | +++ |
| CAS numbers (where available) | +++ | +++ | +++ | ++ |
| Strucutre Data Files (SDF) | +++ | +++ | +++ | +++ |
| Reconstitution information | +++ | N/A | N/A | N/A |
| Pathway description | +++ | N/A | N/A | N/A |
| PubChem compound ID (where available) | +++ | +++ | ++ | Data not provided |
| Assay layout sheet | N/A | +++ | +++ | +++ |
| * Pertains to the majority of inhibitors Δ Each panel also include 15 ml of anhydrous DMSO |
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