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344300 sFRP-1 Inhibitor - CAS 915754-88-0 - Calbiochem

The sFRP-1 Inhibitor, also referenced under CAS 915754-88-0, controls the biological activity of sFRP-1. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-(3-(Dimethylamino)propyl)-2-ethyl-5-(phenylsulfonyl)benzenesulfonamide, Secreted Frizzled Related Protein-1 Inhibitor, Wnt Pathway Activator IV

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344300
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
915754-88-0C₁₉H₂₆N₂O₄S₂

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344300-5MG
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      Description
      OverviewA diphenylsulfone-sulfonamide compound that counteracts the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and Wnt-3/frizzled-stimulated cellular functions (EC50 = 1.27 µM in a U2OS-based reporter assay) with a reported aqueous solubility of 26 µg/ml at pH 7.4 and in vitro half-lives of 12 and 26.7 min using rat and human microsomes, respectively.
      Catalogue Number344300
      Brand Family Calbiochem®
      SynonymsN-(3-(Dimethylamino)propyl)-2-ethyl-5-(phenylsulfonyl)benzenesulfonamide, Secreted Frizzled Related Protein-1 Inhibitor, Wnt Pathway Activator IV
      References
      ReferencesGopalsamy, A., et al. 2008. J. Med. Chem. 51, 7670.
      Product Information
      CAS number915754-88-0
      FormClear oil
      Hill FormulaC₁₉H₂₆N₂O₄S₂
      Chemical formulaC₁₉H₂₆N₂O₄S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      344300-5MG 04055977214710

      Documentation

      sFRP-1 Inhibitor - CAS 915754-88-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      sFRP-1 Inhibitor - CAS 915754-88-0 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      344300

      Références bibliographiques

      Aperçu de la référence bibliographique
      Gopalsamy, A., et al. 2008. J. Med. Chem. 51, 7670.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-April-2011 RFH
      SynonymsN-(3-(Dimethylamino)propyl)-2-ethyl-5-(phenylsulfonyl)benzenesulfonamide, Secreted Frizzled Related Protein-1 Inhibitor, Wnt Pathway Activator IV
      DescriptionA diphenylsulfone-sulfonamide compound that counteracts the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and Wnt-3/frizzled-stimulated cellular functions (EC50 = 1.27 µM in a U2OS-based reporter assay) with a reported aqueous solubility of 26 µg/ml at pH 7.4 and in vitro half-lives of 12 and 26.7 min using rat and human microsomes, respectively.
      FormClear oil
      Intert gas (Yes/No) Packaged under inert gas
      CAS number915754-88-0
      Chemical formulaC₁₉H₂₆N₂O₄S₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGopalsamy, A., et al. 2008. J. Med. Chem. 51, 7670.