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508508 Zonisamide - CAS 68291-97-4 - Calbiochem

An antiepileptic agent that blocks voltage-dependent Na(+) channels and T-type Ca(2+) channels.

Zonisamide - CAS 68291-97-4 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: AD 810, CI 912

Primary Target: Na+ and Ca2+ channels
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508508
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Tableau de caractéristiques principal

CAS #Empirical Formula
68291-97-4C₈H₈N₂O₃S

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      Description
      OverviewA benzisoxazole derivative that acts as an antiepileptic agent and is shown to block voltage-dependent Na(+) channels and T-type Ca(2+) channels. However, it does not serve as anticonvulsant agent in chemically induced seizures in flurothyl and pentetrazole models. Acts as an inhibitor of monoamine oxidase B (MAO-B; IC50 = 24.8 µM). Displays neurprotective properties.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number508508
      Brand Family Calbiochem®
      SynonymsAD 810, CI 912
      References
      ReferencesSonsalla, P.K., et al. 2010. Exp. Neurol. 221, 329.
      Sobieszek, G. et al. 2003. Pol. J. Pharmacol. 55, 68.
      Product Information
      CAS number 68291-97-4
      FormWhite solid
      Hill FormulaC₈H₈N₂O₃S
      Chemical formulaC₈H₈N₂O₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNa+ and Ca2+ channels
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 36/37/39-45-46

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      If swallowed, seek medical advice immediately and show this container or label.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5085080001 04055977262018

      Documentation

      Zonisamide - CAS 68291-97-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Sonsalla, P.K., et al. 2010. Exp. Neurol. 221, 329.
      Sobieszek, G. et al. 2003. Pol. J. Pharmacol. 55, 68.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-January-2014 JSW
      SynonymsAD 810, CI 912
      DescriptionA benzisoxazole derivative that acts as an antiepileptic agent and is shown to block voltage-dependent Na(+) channels and T-type Ca(2+) channels. However, it does not serve as anticonvulsant agent in chemically induced seizures in flurothyl and pentetrazole models. Acts as an inhibitor of monoamine oxidase B (MAO-B; IC50 = 24.8 µM). Displays neurprotective properties.
      FormWhite solid
      CAS number 68291-97-4
      Chemical formulaC₈H₈N₂O₃S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Toxicity Harmful
      ReferencesSonsalla, P.K., et al. 2010. Exp. Neurol. 221, 329.
      Sobieszek, G. et al. 2003. Pol. J. Pharmacol. 55, 68.