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681672 Wnt/β-catenin Inhibitor, Cardamonin - CAS 19309-14-9 - Calbiochem

The Wnt/β-catenin Inhibitor, Cardamonin, also referenced under CAS 19309-14-9, controls the biological activity of Wnt/β-catenin. This small molecule/inhibitor is primarily used for Cancer applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Wnt Pathway Inhibitor VII, Cardamonin, (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one

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681672
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Tableau de caractéristiques principal

CAS #Empirical Formula
19309-14-9C₁₆H₁₄O₄

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681672-2MG
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      Description
      OverviewCardamonin, a known 2',4'-dihydroxy-6'-methoxychalcone, was identified as an inhibitor of melanocyte differentiation, among many other pharmacology activities. Cardamonin promoted degradation of intracellular β-catenin while suppressing melanogenesis by down-regulating the expression of MITF and tyrosinase, resulting in decreased melanin content. Furthermore, it was found that cardamonin promoted the degradation of β-catenin through a GSK-3β-independent mechanism, which suggested that Siah-dependent pathway and/or a PKCα-dependent pathway, rather than a GSK-3β-dependent pathway, may mediate intracellularb-catenin degradation by cardamonin.
      Catalogue Number681672
      Brand Family Calbiochem®
      SynonymsWnt Pathway Inhibitor VII, Cardamonin, (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one
      References
      Product Information
      CAS number19309-14-9
      FormOrange-yellow to amber solid
      Hill FormulaC₁₆H₁₄O₄
      Chemical formulaC₁₆H₁₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      681672-2MG 04055977225204

      Documentation

      Wnt/β-catenin Inhibitor, Cardamonin - CAS 19309-14-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Wnt/β-catenin Inhibitor, Cardamonin - CAS 19309-14-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      681672
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2010 RFH
      SynonymsWnt Pathway Inhibitor VII, Cardamonin, (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one
      DescriptionCardamonin, a known 2',4'-dihydroxy-6'-methoxychalcone, was recently identified as an inhibitor of melanocyte differentiation, among many other pharmacology activities. Cardamonin promoted degradation of intracellular β-catenin while suppressing melanogenesis by down-regulating the expression of MITF and tyrosinase, resulting in decreased melanin content. Furthermore, it was found that cardamonin promoted the degradation of β-catenin through a GSK-3β-independent mechanism, which suggested that Siah-dependent pathway and/or a PKCa-dependent pathway, rather than a GSK-3&beta:-dependent pathway, may mediate intracellularb-catenin degradation by cardamonin.
      FormOrange-yellow to amber solid
      CAS number19309-14-9
      Chemical formulaC₁₆H₁₄O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling